{"doi":"10.1152/jn.00177.2024","title":"Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience","abstract":"By using electrochemical oxygen sensors in freely moving rats, we show that intravenous fentanyl induces opposite changes in brain oxygen at varying doses, increasing at lower doses (<10 µg/kg) and inducing a biphasic response, decrease followed by increase, at higher doses (>10-90 µg/kg). In contrast, fentanyl-induced dose-dependent oxygen decreases in the subcutaneous space. We consider the mechanisms underlying distinct oxygen responses in the brain and periphery and discuss naloxone's role in alleviating fentanyl-induced brain hypoxia.","journal":"Journal of Neurophysiology","year":2024,"id":452787,"datarank":0.45972002716098154,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.10003573624122584,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.10003573624122584,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":true,"deposit_databanks":{"figshare":["10.6084/m9.figshare.25898848"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1042351,"name":"Michael R. Noya","orcid":null,"position":1,"is_corresponding":false},{"id":356294,"name":"Eugene A. Kiyatkin","orcid":"0000-0002-3744-0873","position":2,"is_corresponding":false},{"id":824084,"name":"Shinbe Choi","orcid":"0009-0006-3505-4318","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:02:54.415477Z","pmid":"38863429","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}