{"doi":"10.1152/japplphysiol.00586.2024","title":"Early elevations in arterial pressure: a contributor to rapid depressive symptom emergence in female Zucker rats with metabolic disease?","abstract":"We provide novel insight that the superior maintenance of cerebrovascular endothelial function in female versus male rats with chronic metabolic disease buffers myogenic activation of cerebral resistance arteries/arterioles despite worsening hypertension. As hypertension development is earlier and more severe in females, potentially due to an elevated stress response, the blunted myogenic activation allows greater arterial pressure wave penetrance into the cerebral microcirculation and is associated with accelerated emergence/severity of depressive symptoms in obese female rats.","journal":"Journal of Applied Physiology","year":2024,"id":477661,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1316294,"name":"Lujaina Kamar","orcid":null,"position":1,"is_corresponding":false},{"id":1316295,"name":"Isabel Zimmerman","orcid":null,"position":2,"is_corresponding":false},{"id":975003,"name":"Shawn N. Whitehead","orcid":"0000-0003-4728-8067","position":3,"is_corresponding":false},{"id":278401,"name":"Daniel Goldman","orcid":"0000-0002-8707-5536","position":4,"is_corresponding":false},{"id":535452,"name":"Jefferson C. Frisbee","orcid":"0000-0003-2751-0599","position":5,"is_corresponding":false},{"id":735351,"name":"Filip Konečný","orcid":"0000-0001-5930-8040","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:06:37.812633Z","pmid":"39359187","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}