{"doi":"10.1152/japplphysiol.00509.2023","title":"Serotonin therapies for opioid-induced disordered swallow and respiratory depression","abstract":"This is the first study, to our knowledge, to evaluate sex-specific effects of opioid administration on pharyngeal swallow. We expand on a small but growing number of studies that report a lower threshold for opioid-induced respiratory depression in females compared with males, and we are the first to produce this effect with the partial μ-opioid-receptor agonist buprenorphine. This is the first demonstration, to our knowledge, that activation of 5-HT 1A receptors can improve swallow and breathing outcomes following systemic buprenorphine administration.","journal":"Journal of Applied Physiology","year":2024,"id":463115,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1293679,"name":"In Morimoto","orcid":null,"position":1,"is_corresponding":false},{"id":1293680,"name":"Nathan Fielder","orcid":null,"position":2,"is_corresponding":false},{"id":827600,"name":"Nicholas Mellen","orcid":"0000-0003-2946-8945","position":3,"is_corresponding":false},{"id":402939,"name":"Kimberly Iceman","orcid":"0000-0002-9004-3893","position":4,"is_corresponding":false},{"id":374575,"name":"Teresa Pitts","orcid":"0000-0001-9448-2175","position":5,"is_corresponding":false},{"id":760051,"name":"Michael Frazure","orcid":"0000-0002-8775-7692","position":0,"is_corresponding":true}],"reference_count":118,"raw_metadata":null,"created_at":"2026-07-19T02:04:28.838123Z","pmid":"38385184","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}