{"doi":"10.1152/japplphysiol.00435.2023","title":"Gene–exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial","abstract":"Interindividual differences have been reported in brain health-related outcomes in response to exercise interventions in adults, which could be partially explained by genetic background differences. However, the role of genetic polymorphisms on brain health-related outcomes in response to exercise interventions remains unexplored in pediatric population. The current study in children with overweight/obesity showed that a genetic score composed of six brain health-related polymorphisms ( BDNF, CREB1, NTRK2, COMT, and APOE) regulated the exercise-induced response on several brain health outcomes, yet mainly and more consistently on cognitive flexibility.","journal":"Journal of Applied Physiology","year":2023,"id":362682,"datarank":0.42655420821940393,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.09697052161897099,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.09697052161897099,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":6,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":true,"deposit_databanks":{"figshare":["10.6084/m9.figshare.23884197"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":229163,"name":"Irene Esteban‐Cornejo","orcid":"0000-0002-0027-1770","position":1,"is_corresponding":false},{"id":703545,"name":"José Mora-González","orcid":"0000-0003-2346-8776","position":2,"is_corresponding":false},{"id":1116216,"name":"Lucia V. Torres‐Lopez","orcid":"0000-0002-0299-987X","position":3,"is_corresponding":false},{"id":962088,"name":"Francisco J. Osuna‐Prieto","orcid":"0000-0002-6546-9534","position":4,"is_corresponding":false},{"id":1116217,"name":"José J. Gil‐Cosano","orcid":"0000-0003-0723-876X","position":5,"is_corresponding":false},{"id":235321,"name":"Shlomit Radom‐Aizik","orcid":"0009-0004-4023-7026","position":6,"is_corresponding":false},{"id":1116218,"name":"Idoia Labayen","orcid":"0000-0002-4334-3287","position":7,"is_corresponding":false},{"id":1116219,"name":"Jonatan R. Ruiz","orcid":"0000-0002-7548-7138","position":8,"is_corresponding":false},{"id":773766,"name":"Signe Altmäe","orcid":"0000-0002-0708-1865","position":9,"is_corresponding":false},{"id":24249,"name":"Francisco B. Ortega","orcid":"0000-0003-2001-1121","position":10,"is_corresponding":false},{"id":773765,"name":"Abel Plaza‐Florido","orcid":"0000-0002-5374-3129","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:14:23.749325Z","pmid":"37589055","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}