{"doi":"10.1152/japplphysiol.00410.2023","title":"Thromboxane-induced cerebral microvascular rarefaction predicts depressive symptom emergence in metabolic disease","abstract":"With clinical studies linking vascular disease risk to depressive symptom emergence, we used obese Zucker rats, a model of chronic metabolic disease, to identify potential mechanistic links between these two negative outcomes. Depressive symptom severity correlated with the extent of cerebrovascular rarefaction, after increased vascular oxidant stress/inflammation and TxA 2 production. Anti-TxA 2 interventions prevasculopathy blunted rarefaction and depressive symptoms, while biosimulation indicated that cerebrovascular rarefaction increased hypoxia within capillary networks as a potential contributing mechanism.","journal":"Journal of Applied Physiology","year":2023,"id":376015,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1139337,"name":"Yuki Bao","orcid":null,"position":1,"is_corresponding":false},{"id":799970,"name":"Krishna K. Singh","orcid":"0000-0002-6097-8401","position":2,"is_corresponding":false},{"id":960648,"name":"Stephanie J. Frisbee","orcid":"0000-0003-1526-1839","position":3,"is_corresponding":false},{"id":73170,"name":"Vladimir Hachinski","orcid":"0000-0002-0487-734X","position":4,"is_corresponding":false},{"id":975003,"name":"Shawn N. Whitehead","orcid":"0000-0003-4728-8067","position":5,"is_corresponding":false},{"id":1138852,"name":"C.W. James Melling","orcid":"0000-0002-7474-1886","position":6,"is_corresponding":false},{"id":566334,"name":"Paul D. Chantler","orcid":"0000-0001-6960-9728","position":7,"is_corresponding":false},{"id":278401,"name":"Daniel Goldman","orcid":"0000-0002-8707-5536","position":8,"is_corresponding":false},{"id":535452,"name":"Jefferson C. Frisbee","orcid":"0000-0003-2751-0599","position":10,"is_corresponding":false},{"id":536098,"name":"Brayden D. Halvorson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:16:28.318749Z","pmid":"37969083","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}