{"doi":"10.1152/japplphysiol.00377.2025","title":"Biomechanical implications of mass loading in a swine model of acute hypoxemic respiratory failure","abstract":"In a ventilated swine model, we isolated the mechanical effects of mass loading from those of lung injury. Despite optimization, positive end-expiratory pressure (PEEP) could not restore baseline pulmonary compliance or lung volumes in either healthy or injured lungs. Partitioned respiratory mechanics and imaging reveal that geometric constraints and load-induced airway closure, demonstrated here for the first time in injured swine, may limit the effectiveness of recruitment maneuvers and optimized PEEP in mass-loaded lungs.","journal":"Journal of Applied Physiology","year":2025,"id":514474,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245820,"name":"Yi Xin","orcid":"0000-0003-0539-809X","position":1,"is_corresponding":false},{"id":1059569,"name":"Marcus Victor","orcid":"0000-0002-5928-0591","position":2,"is_corresponding":false},{"id":1059568,"name":"Timothy G. Gaulton","orcid":"0000-0002-3111-1972","position":3,"is_corresponding":false},{"id":1087660,"name":"Glasiele Alcala","orcid":"0000-0002-0727-1132","position":4,"is_corresponding":false},{"id":426842,"name":"Tilo Winkler","orcid":"0000-0002-7276-5550","position":5,"is_corresponding":false},{"id":435947,"name":"Sarah E. Gerard","orcid":"0000-0001-8101-3150","position":6,"is_corresponding":false},{"id":1377112,"name":"Rehab Naeem Khalid","orcid":"0000-0002-0935-058X","position":7,"is_corresponding":false},{"id":669451,"name":"Rajiv Gupta","orcid":"0000-0002-5882-960X","position":8,"is_corresponding":false},{"id":655504,"name":"Emanuele Rezoagli","orcid":"0000-0002-4506-7212","position":9,"is_corresponding":false},{"id":285966,"name":"Lorenzo Berra","orcid":"0000-0003-2702-2093","position":10,"is_corresponding":false},{"id":317175,"name":"Marcelo B. P. Amato","orcid":"0000-0003-3525-8282","position":11,"is_corresponding":false},{"id":339141,"name":"Jason H. T. Bates","orcid":"0000-0002-6062-6377","position":12,"is_corresponding":false},{"id":655507,"name":"Maurizio Cereda","orcid":"0000-0002-2435-7413","position":13,"is_corresponding":false},{"id":1259548,"name":"Alice Nova","orcid":"0000-0002-3769-6406","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:48:29.165853Z","pmid":"40864615","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}