{"doi":"10.1152/japplphysiol.00194.2021","title":"Muscle-specific deletion of the vitamin D receptor in mice is associated with diaphragm muscle weakness","abstract":"Vitamin D deficiency and vitamin D receptor (VDR) polymorphisms are associated with adverse pulmonary and diaphragm muscle (DIAm)-associated respiratory outcomes. We used a skeletal muscle-specific tamoxifen-inducible VDR knockout to investigate DIAm dysfunction following reduced VDR signaling. Marked DIAm weakness and atrophy of type IIx and/or IIb fibers are present in muscle-specific tamoxifen-induced VDR knockout mice compared with controls. These results show that the VDR has a significant biological effect on DIAm function independent of systemic effects on mineral metabolism.","journal":"Journal of Applied Physiology","year":2021,"id":191894,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":758991,"name":"Louis L. Losbanos","orcid":null,"position":1,"is_corresponding":false},{"id":737847,"name":"Theodore A. Craig","orcid":null,"position":2,"is_corresponding":false},{"id":758286,"name":"Carmen J. Reynolds","orcid":"0000-0002-4372-6122","position":3,"is_corresponding":false},{"id":693504,"name":"Alyssa Brown","orcid":"0000-0003-4422-3356","position":4,"is_corresponding":false},{"id":500996,"name":"Rajiv Kumar","orcid":"0000-0003-3497-3057","position":5,"is_corresponding":false},{"id":313780,"name":"Gary C. Sieck","orcid":"0000-0003-3040-9424","position":6,"is_corresponding":false},{"id":379270,"name":"Matthew J. Fogarty","orcid":"0000-0003-0128-7042","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-18T23:49:39.281850Z","pmid":"34013750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}