{"doi":"10.1152/ajprenal.00563.2018","title":"Bile acid signaling in renal water regulation","abstract":"<jats:p>Emerging evidence has shown that bile acids play important roles in renal physiology and diseases by activating two major receptors, the nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor-1 (Gpbar1; also known as TGR5). Both FXR and TGR5 have been identified in human and rodent kidneys, where they are deeply involved in renal water handling. In mice, FXR- or TGR5-related gene deficiency has been associated with reduced aquaporin-2 expression accompanied with impaired urinary concentration ability. In this mini-review, we briefly discuss the current understanding of FXR/TGR5 signaling in the kidneys, with a special focus on the regulation of aquaporin-2 expression by bile acids in the collecting ducts and its potential significance in disease conditions.</jats:p>","journal":"American Journal of Physiology-Renal Physiology","year":2019,"id":654004,"datarank":1.1302558384363555,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.6251614639383842,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.6251614639383842,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":23,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246650,"name":"Chunling Li","orcid":"0000-0002-9381-2686","position":1,"is_corresponding":false},{"id":154559,"name":"Weidong Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1706678,"name":"Suchun Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Bile acid signaling in renal water regulation","abstract":"<jats:p>Emerging evidence has shown that bile acids play important roles in renal physiology and diseases by activating two major receptors, the nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor-1 (Gpbar1; also known as TGR5). Both FXR and TGR5 have been identified in human and rodent kidneys, where they are deeply involved in renal water handling. In mice, FXR- or TGR5-related gene deficiency has been associated with reduced aquaporin-2 expression accompanied with impaired urinary concentration ability. In this mini-review, we briefly discuss the current understanding of FXR/TGR5 signaling in the kidneys, with a special focus on the regulation of aquaporin-2 expression by bile acids in the collecting ducts and its potential significance in disease conditions.</jats:p>","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31091123","pmcid":null,"openalex_id":"https://openalex.org/W2946787461","authors":[],"funders":[],"total_grants":0,"fwci":0.4466,"citation_percentile":0.64300511,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":6},{"year":2024,"count":10},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00563.2018","host_type":"journal"},{"url":"https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00563.2018","host_type":"publisher"},{"url":"https://www.physiology.org/doi/pdf/10.1152/ajprenal.00563.2018","host_type":"publisher"},{"url":"https://doi.org/10.1152/ajprenal.00563.2018","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31091123","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Ion Transport and Channel Regulation","Pediatric Hepatobiliary Diseases and Treatments","Animals","Aquaporin 2","Bile Acids and Salts","Humans","Kidney","Receptors, Cytoplasmic and Nuclear","Receptors, G-Protein-Coupled","Signal Transduction","Water","Water-Electrolyte Balance","Receptor, Farnesoid X-Activated"],"mesh_terms":["Receptor, Farnesoid X-Activated","Animals","Bile Acids and Salts","Humans","Kidney","Water","Water-Electrolyte Balance","Signal Transduction","Receptors, Cytoplasmic and Nuclear","Receptors, G-Protein-Coupled","Aquaporin 2"],"keywords":["Farnesoid X receptor","G protein-coupled bile acid receptor","Bile acid","Nuclear receptor","Receptor","Aquaporin","Biology","Aquaporin 2","Signal transduction","Kidney","Internal medicine","Endocrinology","Cell biology","Biochemistry","Medicine","Gene","Water channel","Transcription factor","Aquaporin-2","Bile acids","G Protein-coupled Bile Acid Receptor-1"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T02:43:44.633595Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}