{"doi":"10.1152/ajplung.00334.2023","title":"TrkB signaling promotes alveolar capillary angiogenesis following perinatal hyperoxic damage","abstract":"<jats:p>The present study highlights the essential role of BDNF/TrkB signaling in capillary endothelial cell proliferation and preserving alveolar architecture during perinatal hyperoxic lung injury, supporting the concept that activation of TrkB/MAPK/ERK signaling might be a strategy to restore alveolar angiogenesis for preterm infants at risk of BPD.</jats:p>","journal":"American Journal of Physiology-Lung Cellular and Molecular Physiology","year":2025,"id":611918,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1575253,"name":"Hanxiang Liu","orcid":null,"position":1,"is_corresponding":false},{"id":730211,"name":"Ming Liu","orcid":"0000-0001-5138-9640","position":2,"is_corresponding":false},{"id":674098,"name":"Yanli Wang","orcid":"0000-0001-8808-3370","position":3,"is_corresponding":false},{"id":1575254,"name":"Yutian Lai","orcid":null,"position":4,"is_corresponding":false},{"id":1154327,"name":"Yuchen Zhao","orcid":"0000-0002-1935-8147","position":5,"is_corresponding":false},{"id":897578,"name":"Ming Li","orcid":"0000-0001-6665-8559","position":6,"is_corresponding":false},{"id":1575255,"name":"Yanru Liu","orcid":null,"position":7,"is_corresponding":false},{"id":384808,"name":"Chong Ma","orcid":"0000-0003-0837-435X","position":8,"is_corresponding":false},{"id":1575256,"name":"Jiashuang Lai","orcid":null,"position":9,"is_corresponding":false},{"id":1022458,"name":"Hanmin Liu","orcid":"0000-0002-4633-911X","position":10,"is_corresponding":false},{"id":329763,"name":"Hua He","orcid":"0009-0003-2585-7684","position":11,"is_corresponding":false},{"id":1251044,"name":"Fei Sun","orcid":"0000-0002-0638-9948","position":12,"is_corresponding":false},{"id":1323043,"name":"Xinhua Lin","orcid":"0009-0004-6561-8394","position":13,"is_corresponding":false},{"id":1241580,"name":"Qing Ma","orcid":"0000-0003-0739-2281","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TrkB signaling promotes alveolar capillary angiogenesis following perinatal hyperoxic damage","abstract":"<jats:p>The present study highlights the essential role of BDNF/TrkB signaling in capillary endothelial cell proliferation and preserving alveolar architecture during perinatal hyperoxic lung injury, supporting the concept that activation of TrkB/MAPK/ERK signaling might be a strategy to restore alveolar angiogenesis for preterm infants at risk of BPD.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40125780","pmcid":null,"openalex_id":"https://openalex.org/W4408772103","authors":[],"funders":[{"funder_name":"MOST | National Key Research and Development Program of China","grant_id":"2022YFA0806200","title":null},{"funder_name":"MOST | National Natural Science Foundation of China","grant_id":"32192400","title":null},{"funder_name":"MOST | National Natural Science Foundation of China","grant_id":"82271748","title":null},{"funder_name":"MOST | National Natural Science Foundation of China","grant_id":"82200098","title":null},{"funder_name":"MOST | National Natural Science Foundation of China","grant_id":"81700219","title":null},{"funder_name":"MOE | Fundamental Research Funds for the Central Universities","grant_id":"SCU2022D006","title":null},{"funder_name":"Fudan University","grant_id":"No. SKLGE-2306","title":null}],"total_grants":7,"fwci":1.5112,"citation_percentile":0.80238794,"influential_citations":0,"citation_trend":[{"year":2026,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://journals.physiology.org/doi/pdf/10.1152/ajplung.00334.2023","host_type":"journal"},{"url":"https://journals.physiology.org/doi/pdf/10.1152/ajplung.00334.2023","host_type":"publisher"},{"url":"https://doi.org/10.1152/ajplung.00334.2023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40125780","host_type":"repository"}],"fields_of_study":["Neonatal Respiratory Health Research","Congenital Diaphragmatic Hernia Studies","Respiratory Support and Mechanisms","Animals","Hyperoxia","Receptor, trkB","Brain-Derived Neurotrophic Factor","Mice","Pulmonary Alveoli","Signal Transduction","Cell Proliferation","Bronchopulmonary Dysplasia","Capillaries","Neovascularization, Physiologic","Mice, Inbred C57BL","Endothelial Cells","Humans","Female","Animals, Newborn","MAP Kinase Signaling System","Neovascularization, Pathologic","Angiogenesis"],"mesh_terms":["Angiogenesis","Animals","Animals, Newborn","Bronchopulmonary Dysplasia","Capillaries","Female","Humans","Mice, Inbred C57BL","Neovascularization, Pathologic","Pulmonary Alveoli","Signal Transduction","Hyperoxia","Neovascularization, Physiologic","Brain-Derived Neurotrophic Factor","Receptor, trkB","MAP Kinase Signaling System","Endothelial Cells","Cell Proliferation","Mice"],"keywords":["Tropomyosin receptor kinase B","Angiogenesis","Hyperoxia","Bronchopulmonary dysplasia","Kinase insert domain receptor","Vascular endothelial growth factor","Cancer research","Cell biology","Vascular endothelial growth factor A","Biology","Lung","Medicine","Internal medicine","Receptor","Neurotrophic factors","TrkB","Endothelial Cell","Gcap","Perinatal Injury","Pulmonary Angiogenesis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T23:45:27.619600Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}