{"doi":"10.1152/ajplung.00331.2024","title":"Carbonic anhydrase IX promotes acute lung injury and mortality in females during metabolic acidosis and pneumonia","abstract":"Acidosis is prevalent in patients with ARDS, yet the mechanisms involved in alveolar-capillary dysfunction during metabolic acidosis and lung injury remain poorly defined. Here, we report that carbonic anhydrase IX, a unique pH regulatory protein, promotes pulmonary edema and mortality but does not affect lung bacterial clearance during metabolic acidosis and pneumonia. Our findings suggest that carbonic anhydrase IX may serve as a therapeutic target to alleviate lung injury in patients with acidosis and ARDS.","journal":"American Journal of Physiology-Lung Cellular and Molecular Physiology","year":2025,"id":534090,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1416681,"name":"J. L. Holston","orcid":null,"position":1,"is_corresponding":false},{"id":1416682,"name":"Karam Maatouk","orcid":null,"position":2,"is_corresponding":false},{"id":675154,"name":"Chun Zhou","orcid":"0000-0003-2640-5842","position":3,"is_corresponding":false},{"id":1416683,"name":"Madeline Stone","orcid":null,"position":4,"is_corresponding":false},{"id":792386,"name":"Viktoriya Pastukh","orcid":null,"position":5,"is_corresponding":false},{"id":519036,"name":"C. Michael Francis","orcid":"0000-0001-6001-2618","position":6,"is_corresponding":false},{"id":1416244,"name":"Sagar Kumar","orcid":"0000-0001-5769-1162","position":7,"is_corresponding":false},{"id":286507,"name":"M.S. Gwin","orcid":"0000-0002-3084-8032","position":8,"is_corresponding":false},{"id":827002,"name":"Sarah Sayner","orcid":"0000-0002-4587-6634","position":9,"is_corresponding":false},{"id":286509,"name":"Troy Stevens","orcid":"0000-0001-9689-929X","position":10,"is_corresponding":false},{"id":585726,"name":"Ji Lee","orcid":"0000-0002-8005-2446","position":11,"is_corresponding":false},{"id":519038,"name":"R.P. Stevens","orcid":"0000-0001-9209-9527","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:51:43.451278Z","pmid":"40623021","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}