{"doi":"10.1152/ajplung.00323.2024","title":"The mysterious case of missing lymphocytes: a cautionary tale of interinstitutional variability in outcomes of lung dissociation protocols","abstract":"Rigor and reproducibility are vital to scientific advancement. It is unclear whether a protocol optimized for tissue dissociation in one institution performs well universally. Here, the authors share their experience with interinstitutional variability that led to the discovery that a protocol optimized for murine lung dissociation in one institution failed to reproduce similar lymphocyte outcomes elsewhere. This report, thus, serves as a cautionary tale against directly adopting tissue dissociation protocols across institutions without reoptimization.","journal":"American Journal of Physiology-Lung Cellular and Molecular Physiology","year":2025,"id":542720,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9419,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1380606,"name":"Vijay Raaj Ravi","orcid":"0000-0001-9489-1606","position":1,"is_corresponding":false},{"id":1070496,"name":"Fang Ke","orcid":"0000-0001-8011-147X","position":2,"is_corresponding":false},{"id":907126,"name":"Nathan L. Sanders","orcid":"0000-0003-3720-2848","position":3,"is_corresponding":false},{"id":723144,"name":"Elise Armstrong","orcid":"0000-0002-2762-5006","position":4,"is_corresponding":false},{"id":89954,"name":"Joseph P. Mizgerd","orcid":"0000-0002-4042-3169","position":5,"is_corresponding":false},{"id":422668,"name":"Anukul T. Shenoy","orcid":"0000-0001-8861-2295","position":6,"is_corresponding":false},{"id":976660,"name":"Olivia Harlow","orcid":"0000-0001-8142-8698","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T02:53:00.171379Z","pmid":"39786964","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}