{"doi":"10.1152/ajplung.00227.2024","title":"β-Ionone facilitates ex vivo airway smooth muscle relaxation via extraocular opsin-3 light receptor activation","abstract":"This research investigates β-ionone's potential as a therapeutic agent for bronchoconstriction. It sheds light on the mechanism of action of β-ionone's activation of extraocular opsin-3 receptors, offering insights into dietary influences on respiratory health. Notably, β-ionone induces dose-dependent relaxation in both upper and lower airways, with attenuated relaxation in Opn3-knockout models confirming receptor selectivity. This study presents a novel approach to addressing respiratory ailments and underscores the significance of dietary components in managing airway pathology.","journal":"American Journal of Physiology-Lung Cellular and Molecular Physiology","year":2025,"id":551633,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1447709,"name":"Eyar Shany","orcid":null,"position":1,"is_corresponding":false},{"id":805412,"name":"Yi Zhang","orcid":"0000-0001-5388-1276","position":2,"is_corresponding":false},{"id":415784,"name":"Amy D. Wu","orcid":"0000-0003-4983-2724","position":3,"is_corresponding":false},{"id":415785,"name":"William Dan","orcid":"0000-0002-9154-8391","position":4,"is_corresponding":false},{"id":458722,"name":"Jose F. Perez‐Zoghbi","orcid":"0000-0002-7554-6468","position":5,"is_corresponding":false},{"id":485294,"name":"Charles W. Emala","orcid":"0000-0003-0248-4662","position":6,"is_corresponding":false},{"id":415783,"name":"Peter D. Yim","orcid":"0000-0003-1670-7599","position":7,"is_corresponding":false},{"id":1447295,"name":"S. Uribe","orcid":"0009-0005-2238-1814","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:54:25.065895Z","pmid":"39937635","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}