{"doi":"10.1152/ajplung.00195.2002","title":"Implications for matrix metalloproteinases as modulators of pediatric lung disease","abstract":"<jats:p>Matrix metalloproteinases (MMPs) are a large family (&gt;20) of cation-dependent proteinases believed to be important modulators of normal human lung development and potentially harmful mediators of lung damage. Little is known about MMP production and secretion by the lung during childhood or how alterations in MMP levels may be involved in lung damage. We examined endotracheal aspirates from children (&lt;19 years) without lung disease for the presence of MMP activity. Only gelatinase activity was detectable, and inhibitor profiles suggest they represented one or more MMPs. Comparison of gelatinase activity, MMP expression, and MMP activity in children without pulmonary disease with children who required mechanical ventilation for respiratory failure show: 1) gelatinase activity was approximately five- to sixfold higher in respiratory failure; 2) MMP-7, MMP-8, and MMP-9 concentrations and MMP-8 and MMP-9 activities were markedly elevated in respiratory failure; and 3) MMP-7, MMP-8, and MMP-9 levels were significantly correlated in children with lung disease. These studies provide compelling evidence that specific MMPs are present in the diseased lung and may participate in the pathogenesis of pediatric respiratory failure.</jats:p>","journal":"American Journal of Physiology-Lung Cellular and Molecular Physiology","year":2003,"id":656638,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1714040,"name":"Jane K. Foldes","orcid":null,"position":1,"is_corresponding":false},{"id":1714043,"name":"Robert C. Bunn","orcid":null,"position":2,"is_corresponding":false},{"id":377411,"name":"John L. Fowlkes","orcid":null,"position":3,"is_corresponding":false},{"id":1714037,"name":"Margaret K. Winkler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Implications for matrix metalloproteinases as modulators of pediatric lung disease","abstract":"<jats:p>Matrix metalloproteinases (MMPs) are a large family (&gt;20) of cation-dependent proteinases believed to be important modulators of normal human lung development and potentially harmful mediators of lung damage. Little is known about MMP production and secretion by the lung during childhood or how alterations in MMP levels may be involved in lung damage. We examined endotracheal aspirates from children (&lt;19 years) without lung disease for the presence of MMP activity. Only gelatinase activity was detectable, and inhibitor profiles suggest they represented one or more MMPs. Comparison of gelatinase activity, MMP expression, and MMP activity in children without pulmonary disease with children who required mechanical ventilation for respiratory failure show: 1) gelatinase activity was approximately five- to sixfold higher in respiratory failure; 2) MMP-7, MMP-8, and MMP-9 concentrations and MMP-8 and MMP-9 activities were markedly elevated in respiratory failure; and 3) MMP-7, MMP-8, and MMP-9 levels were significantly correlated in children with lung disease. These studies provide compelling evidence that specific MMPs are present in the diseased lung and may participate in the pathogenesis of pediatric respiratory failure.</jats:p>","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12456387","pmcid":null,"openalex_id":"https://openalex.org/W2155313960","authors":[],"funders":[],"total_grants":0,"fwci":0.9188,"citation_percentile":0.74956438,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2016,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.physiology.org/doi/pdf/10.1152/ajplung.00195.2002","host_type":"publisher"},{"url":"https://doi.org/10.1152/ajplung.00195.2002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12456387","host_type":"repository"}],"fields_of_study":["Protease and Inhibitor Mechanisms","Blood Coagulation and Thrombosis Mechanisms","Neonatal Respiratory Health Research"],"mesh_terms":["Adolescent","Adult","Bronchoalveolar Lavage Fluid","Child","Child, Preschool","Extracellular Matrix","Female","Humans","Infant","Lung","Lung Diseases","Male","Respiration, Artificial","Respiratory Insufficiency","Matrix Metalloproteinase 2","Matrix Metalloproteinase 9","Matrix Metalloproteinases","Matrix Metalloproteinase 7","Matrix Metalloproteinase 8"],"keywords":["Matrix metalloproteinase","Gelatinase","Lung","Respiratory disease","Matrix metalloproteinase inhibitor","Respiratory system","Pathogenesis","Respiratory failure","Gelatinase A","Medicine","Pathology","Immunology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T21:36:57.362230Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}