{"doi":"10.1152/ajplung.00050.2024","title":"Downregulation of protein phosphatase 2Aα in asthmatic airway smooth muscle","abstract":"This novel study deciphered the expression and function of protein phosphatase 2Aα (PP2Aα) in airway smooth muscle (ASM) during asthma and/or inflammation. We showed robust expression of PP2Aα in human ASM while its downregulation in asthmatic ASM. Similarly, we demonstrated reduced PP2Aα expression in ASM exposed to proinflammatory cytokines. PP2Aα activation inhibited bronchoconstriction of isolated mouse bronchi. In addition, we unveiled that PP2Aα activation inhibits the intracellular calcium release and myosin light chain phosphorylation in human ASM.","journal":"American Journal of Physiology-Lung Cellular and Molecular Physiology","year":2024,"id":444383,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9607,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":613761,"name":"Ashish Kumar","orcid":"0000-0002-2003-6209","position":1,"is_corresponding":false},{"id":426201,"name":"Christina M. Pabelick","orcid":"0000-0002-4632-2174","position":2,"is_corresponding":false},{"id":649671,"name":"Rodney D. Britt","orcid":"0000-0002-0027-9545","position":3,"is_corresponding":false},{"id":245519,"name":"Y. S. Prakash","orcid":"0000-0002-2968-224X","position":4,"is_corresponding":false},{"id":420821,"name":"Venkatachalem Sathish","orcid":"0000-0001-9770-8299","position":5,"is_corresponding":false},{"id":1259473,"name":"Mohammad Irshad Reza","orcid":"0000-0002-0013-2340","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:01:33.526738Z","pmid":"38529552","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}