{"doi":"10.1152/ajpheart.00264.2022","title":"The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence?","abstract":"Working from an established database spanning multiple scales and times, we studied progression of peripheral microvascular dysfunction in chronic metabolic disease. The data implicate the postcapillary venular endothelium as the initiating site for vasculopathy. Indicators of dysfunction, spanning network structures, hemodynamics, vascular reactivity, and perfusion progress in an insidious retrograde manner to present as functional impairments to muscle blood flow and performance much later. The silent vasculopathy progression may provide insight into clinical treatment challenges.","journal":"American Journal of Physiology-Heart and Circulatory Physiology","year":2022,"id":283793,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9226,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":961058,"name":"Nithin J. Menon","orcid":null,"position":1,"is_corresponding":false},{"id":278401,"name":"Daniel Goldman","orcid":"0000-0002-8707-5536","position":2,"is_corresponding":false},{"id":960648,"name":"Stephanie J. Frisbee","orcid":"0000-0003-1526-1839","position":3,"is_corresponding":false},{"id":735165,"name":"Adam G. Goodwill","orcid":"0000-0003-3701-3713","position":4,"is_corresponding":false},{"id":799971,"name":"Joshua T. Butcher","orcid":"0000-0002-7341-1949","position":5,"is_corresponding":false},{"id":887952,"name":"Phoebe A. Stapleton","orcid":"0000-0003-3049-4868","position":6,"is_corresponding":false},{"id":363402,"name":"Steven Brooks","orcid":"0000-0001-7357-1419","position":7,"is_corresponding":false},{"id":961059,"name":"Alexandre C. d’Audiffret","orcid":null,"position":8,"is_corresponding":false},{"id":535454,"name":"Robert W. Wiseman","orcid":"0000-0003-1832-7805","position":9,"is_corresponding":false},{"id":428983,"name":"Julian H. Lombard","orcid":"0000-0002-6920-4736","position":10,"is_corresponding":false},{"id":960649,"name":"Robert W. Brock","orcid":"0000-0002-3783-248X","position":11,"is_corresponding":false},{"id":388694,"name":"I. Mark Olfert","orcid":"0000-0003-3505-9945","position":12,"is_corresponding":false},{"id":566334,"name":"Paul D. Chantler","orcid":"0000-0001-6960-9728","position":13,"is_corresponding":false},{"id":535452,"name":"Jefferson C. Frisbee","orcid":"0000-0003-2751-0599","position":14,"is_corresponding":false},{"id":536098,"name":"Brayden D. Halvorson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:28.452697Z","pmid":"35904886","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}