{"doi":"10.1152/ajpheart.00208.2020","title":"Mechanisms of sympathetic restraint in human skeletal muscle during exercise: role of α-adrenergic and nonadrenergic mechanisms","abstract":"Sympathetic restraint of vascular conductance to inactive skeletal muscle is critical to maintain blood pressure during moderate- to high-intensity whole body exercise. This investigation shows that cycle exercise-induced restraint of inactive skeletal muscle vascular conductance occurs primarily because of activation of α-adrenergic receptors. Furthermore, exercise-induced vasoconstriction restrains the subsequent vasodilatory response to hand-grip exercise; however, the restraint of active skeletal muscle vasodilation was in part due to nonadrenergic mechanisms. We conclude that α-adrenergic receptors are the primary but not exclusive mechanism by which sympathetic vasoconstriction restrains blood flow in humans during whole body exercise and that metabolic activity modulates the contribution of α-adrenergic receptors.","journal":"American Journal of Physiology-Heart and Circulatory Physiology","year":2020,"id":69797,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":319810,"name":"Gilbert Moralez","orcid":"0000-0002-0654-2383","position":1,"is_corresponding":false},{"id":369478,"name":"Steven A. Romero","orcid":"0000-0002-2014-7806","position":2,"is_corresponding":false},{"id":370470,"name":"Christopher Gasho","orcid":null,"position":3,"is_corresponding":false},{"id":369479,"name":"Michael M. Tymko","orcid":"0000-0001-9945-339X","position":4,"is_corresponding":false},{"id":369480,"name":"Philip N. Ainslie","orcid":"0000-0001-6560-222X","position":5,"is_corresponding":false},{"id":369481,"name":"Florian Hofstätter","orcid":"0009-0003-9100-3767","position":6,"is_corresponding":false},{"id":369482,"name":"Simon Ludwig Rainer","orcid":"0000-0002-5158-6625","position":7,"is_corresponding":false},{"id":350884,"name":"Justin S. Lawley","orcid":"0000-0003-2166-7966","position":8,"is_corresponding":false},{"id":369483,"name":"Christopher M. Hearon","orcid":"0000-0002-6561-3532","position":9,"is_corresponding":false},{"id":369477,"name":"Alexander B. Hansen","orcid":"0000-0001-6747-3708","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T21:42:48.813846Z","pmid":"32502375","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}