{"doi":"10.1152/ajpgi.2001.281.6.g1333","title":"III. Peroxisomal β-oxidation, PPARα, and steatohepatitis","abstract":"<jats:p>Peroxisomes are involved in the β-oxidation chain shortening of long-chain and very-long-chain fatty acyl-CoAs, long-chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs, and the CoA esters of the bile acid intermediates, and in the process, they generate H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>. There are two complete sets of β-oxidation enzymes present in peroxisomes, with each set consisting of three distinct enzymes. The classic PPARα-regulated and inducible set participates in the β-oxidation of straight-chain fatty acids, whereas the second noninducible set acts on branched-chain fatty acids. Long-chain and very-long-chain fatty acids are also metabolized by the cytochrome P-450 CYP4A ω-oxidation system to dicarboxylic acids that serve as substrates for peroxisomal β-oxidation. Evidence derived from mouse models of PPARα and peroxisomal β-oxidation deficiency highlights the critical importance of the defects in PPARα-inducible β-oxidation in energy metabolism and in the development of steatohepatitis.</jats:p>","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2001,"id":632695,"datarank":0.8195747707538417,"base_score":5.4638318050256105,"endowment":5.4638318050256105,"self_citation_contribution":0.8195747707538417,"citation_network_contribution":0.0,"self_endowment_contribution":0.8195747707538417,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":235,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":141733,"name":"Janardan K. 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Long-chain and very-long-chain fatty acids are also metabolized by the cytochrome P-450 CYP4A omega-oxidation system to dicarboxylic acids that serve as substrates for peroxisomal beta-oxidation. Evidence derived from mouse models of PPAR alpha and peroxisomal beta-oxidation deficiency highlights the critical importance of the defects in PPAR alpha-inducible beta-oxidation in energy metabolism and in the development of steatohepatitis.","is_dataset_classified":null,"base_score":5.4638318050256105,"endowment":5.4638318050256105,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11705737","pmcid":null,"openalex_id":"https://openalex.org/W2224030459","authors":[],"funders":[],"total_grants":0,"fwci":3.6882,"citation_percentile":0.93879217,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":12},{"year":2014,"count":10},{"year":2015,"count":17},{"year":2016,"count":12},{"year":2017,"count":12},{"year":2018,"count":8},{"year":2019,"count":9},{"year":2020,"count":7},{"year":2021,"count":6},{"year":2022,"count":6},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1152/ajpgi.2001.281.6.g1333","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11705737","host_type":"repository"}],"fields_of_study":["Peroxisome Proliferator-Activated Receptors","Metabolism and Genetic Disorders","Adipose Tissue and Metabolism"],"mesh_terms":["Animals","Energy Metabolism","Fatty Acids","Fatty Liver","Hepatitis","Homeostasis","Humans","Oxidation-Reduction","Transcription Factors","Receptors, Cytoplasmic and Nuclear","Peroxisomal Disorders","Peroxisomes"],"keywords":["Steatohepatitis","Peroxisome","Chemistry","Internal medicine","Biochemistry","Fatty liver","Medicine","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:12:12.815384Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}