{"doi":"10.1152/ajpgi.2001.280.3.g389","title":"Rat colon ornithine and arginine metabolism: coordinated effects after proliferative stimuli","abstract":"<jats:p>Ornithine decarboxylase (ODC) catalyzes the first step in the polyamine biosynthetic pathway, a highly regulated pathway in which activity increases during rapid growth. Other enzymes also metabolize ornithine, and in hepatomas, rate of growth correlates with decreased activity of these other enzymes, which thus channels more ornithine to polyamine biosynthesis. Ornithine is produced from arginase cleavage of arginine, which also serves as the precursor for nitric oxide production. To study whether short-term coordination of ornithine and arginine metabolism exists in rat colon, ODC, ornithine aminotransferase (OAT), arginase, ornithine, arginine, and polyamine levels were measured after two stimuli (refeeding and/or deoxycholate exposure) known to synergistically induce ODC activity. Increased ODC activity was accompanied by increased putrescine levels, whereas OAT and arginase activity were reduced by either treatment, accompanied by an increase in both arginine and ornithine levels. These results indicate a rapid reciprocal change in ODC, OAT, and arginase activity in response to refeeding or deoxycholate. The accompanying increases in ornithine and arginine concentration are likely to contribute to increased flux through the polyamine and nitric oxide biosynthetic pathways in vivo.</jats:p>","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2001,"id":16032,"datarank":0.8626594692947538,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.4779170656755233,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.4779170656755233,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":11,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119870,"name":"Michael N. Kazarinoff","orcid":null,"position":1,"is_corresponding":false},{"id":119872,"name":"Nikolaus Seiler","orcid":null,"position":2,"is_corresponding":false},{"id":119874,"name":"Bruce A. Stanley","orcid":null,"position":3,"is_corresponding":false},{"id":119868,"name":"Xiaoli Han","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11171621","pmcid":null,"openalex_id":"https://openalex.org/W2114655432","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA-26755","title":null}],"total_grants":1,"fwci":0.2327,"citation_percentile":0.54330983,"influential_citations":1,"citation_trend":[{"year":2017,"count":1},{"year":2019,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.physiology.org/doi/pdf/10.1152/ajpgi.2001.280.3.G389","host_type":"publisher"},{"url":"https://doi.org/10.1152/ajpgi.2001.280.3.g389","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11171621","host_type":"repository"}],"fields_of_study":["Polyamine Metabolism and Applications","Amino Acid Enzymes and Metabolism","Cannabis and Cannabinoid Research","Medicine","Biology","Animals","Arginase","Arginine","Biogenic Polyamines","Cell Division","Colon","DNA","Deoxycholic Acid","Food Deprivation","Male","Ornithine","Ornithine Decarboxylase","Ornithine-Oxo-Acid Transaminase","Rats","Rats, Sprague-Dawley"],"mesh_terms":["Animals","Arginase","Arginine","Cell Division","Colon","Deoxycholic Acid","DNA","Food Deprivation","Male","Ornithine","Ornithine-Oxo-Acid Transaminase","Ornithine Decarboxylase","Biogenic Polyamines","Rats, Sprague-Dawley","Rats"],"keywords":["Arginase","Ornithine","Ornithine decarboxylase","Arginine","Citrulline","Polyamine","Nitric oxide","Putrescine","Biochemistry","Ornithine aminotransferase","Ornithine decarboxylase antizyme","Metabolism","Chemistry","Enzyme","Biosynthesis","Biology","Endocrinology","Amino acid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T20:02:10.632877Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}