{"doi":"10.1152/ajpgi.00308.2024","title":"Elucidation of roles of serine/threonine phosphatases PP1 and PP2A in mediating CCK-stimulated growth and enzyme secretion in pancreatic acinar cells","abstract":"Despite more than 10 studies, the roles of the serine/threonine phosphatases, PP1/PP2A, in pancreatic acinar cell-secretion/growth remain controversial. This study demonstrates that both PP1/PP2A are present in rat pancreatic acini and in pancreatic acinar tumor-AR42J cells. Both phosphatases are activated by pancreatic secretagogues, stimulating PLC, and by pancreatic growth factors. Using specific inhibitory conditions for PP1/PP2A (inhibitors, siRNA studies), only PP2A activation is needed for CCK-8-stimulated enzyme secretion and growth signaling cascades in pancreatic acinar cells.","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2025,"id":541214,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":404129,"name":"Robert T. Jensen","orcid":"0000-0002-0095-4600","position":1,"is_corresponding":false},{"id":423258,"name":"Irene Ramos-Álvarez","orcid":null,"position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":null,"created_at":"2026-07-19T02:52:47.161928Z","pmid":"40375576","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}