{"doi":"10.1152/ajpgi.00235.2025","title":"Beyond fructolysis: ketohexokinase orchestrates ER proteostasis in nutrient-stressed hepatocytes","abstract":"This study uncovers a noncanonical role for ketohexokinase (KHK) in maintaining ER proteostasis during nutrient overload. In hepatocytes exposed to fructose and saturated fat, KHK promotes adaptive IRE1α-XBP1 signaling and prevents proteotoxic stress and apoptosis. These findings position KHK as a metabolic checkpoint linking fructose metabolism to ER stress resolution and offer new insight into liver survival pathways relevant to MASLD and MASH.","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2025,"id":535172,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1418752,"name":"Xiangdong Wu","orcid":"0009-0004-8739-9540","position":1,"is_corresponding":false},{"id":1418753,"name":"Junkai Hu","orcid":"0000-0001-8135-8343","position":2,"is_corresponding":false},{"id":717978,"name":"Nigus D. Ambaye","orcid":"0000-0001-5026-6542","position":3,"is_corresponding":false},{"id":874017,"name":"Sui Seng Tee","orcid":"0000-0002-9891-4622","position":4,"is_corresponding":false},{"id":1418751,"name":"Salaheldeen Elsaid","orcid":"0000-0002-8362-9378","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41138206","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}