{"doi":"10.1152/ajpgi.00165.2021","title":"HOPX<sup>+</sup> injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia","abstract":"This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near-complete epithelial loss. Furthermore, we have evidence that HOPX controls ISC activity state and may be a critical signaling pathway during ISC-mediated repair. Finally, we use multiple novel methods to evaluate ISCs in a translationally relevant large animal model of severe intestinal injury and provide evidence for the potential role of rISCs as therapeutic targets.","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2021,"id":168808,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":698425,"name":"Cecilia R. Schaaf","orcid":"0000-0001-9900-8392","position":1,"is_corresponding":false},{"id":392790,"name":"Jennifer Luff","orcid":"0000-0002-0696-0243","position":2,"is_corresponding":false},{"id":698426,"name":"John Freund","orcid":"0009-0006-7530-4449","position":3,"is_corresponding":false},{"id":259351,"name":"Thomas Becker","orcid":"0000-0002-1138-5263","position":4,"is_corresponding":false},{"id":698890,"name":"Sara Tufts","orcid":null,"position":5,"is_corresponding":false},{"id":425851,"name":"James Robertson","orcid":"0000-0002-6115-042X","position":6,"is_corresponding":false},{"id":453100,"name":"Liara M. Gonzalez","orcid":"0000-0003-3972-2812","position":7,"is_corresponding":false},{"id":698424,"name":"Amy Stewart","orcid":"0000-0003-1602-3461","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:06.853307Z","pmid":"34549599","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}