{"doi":"10.1152/ajpgi.00122.2019","title":"Stimulus intensity-dependent recruitment of Na<sub>V</sub>1 subunits in action potential initiation in nerve terminals of vagal C-fibers innervating the esophagus","abstract":"We report that pharmacologically distinguishable voltage-gated sodium channels (Na V 1) mediate action potential initiation at low (innocuous) versus high (noxious) intensity of esophageal distention in nerve terminals of vagal nodose C-fibers. Action potential initiation at low intensity is entirely dependent on Na V 1.7; however, additional tetrodotoxin (TTX)-sensitive Na V 1s are recruited at higher intensity of distention. This is the first demonstration that Na V 1s underlying action potential initiation in visceral C-fibers depend on the intensity of the stimulus.","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2020,"id":111186,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":528366,"name":"Nikoleta Pavelková","orcid":"0000-0001-8240-2174","position":1,"is_corresponding":false},{"id":528367,"name":"Jeffrey L. Krajewski","orcid":"0000-0003-2873-9176","position":2,"is_corresponding":false},{"id":528368,"name":"Jeff S. McDermott","orcid":"0000-0002-6362-3307","position":3,"is_corresponding":false},{"id":528369,"name":"Bradley J. Undem","orcid":"0000-0001-5299-9029","position":4,"is_corresponding":false},{"id":298665,"name":"Marián Kollárik","orcid":"0000-0002-9659-5007","position":5,"is_corresponding":false},{"id":529162,"name":"Fei Ru","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:13:05.597252Z","pmid":"32726130","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}