{"doi":"10.1152/ajpgi.00119.2023","title":"Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammation","abstract":"We report that panaxynol (PA) reduces colorectal cancer (CRC) by improving the colonic and tumor environment. Specifically, we demonstrate that PA improves crypt morphology, upregulates crucial tight junction and mucin genes, and promotes the abundance of mucin-producing goblet cells. Furthermore, PA reduces macrophages and associated inflammation, important drivers of CRC, in the colonic environment. This present study provides novel insights into the potential of PA as a therapeutic agent to ameliorate CRC tumorigenesis.","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2023,"id":343033,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":888235,"name":"Brooke M. Bullard","orcid":"0000-0003-0923-9950","position":1,"is_corresponding":false},{"id":318651,"name":"Brandon N. VanderVeen","orcid":"0000-0002-4535-0544","position":2,"is_corresponding":false},{"id":888234,"name":"Thomas D. Cardaci","orcid":"0000-0002-4339-819X","position":3,"is_corresponding":false},{"id":1080503,"name":"Alexander R. Huss","orcid":null,"position":4,"is_corresponding":false},{"id":396954,"name":"Daping Fan","orcid":"0000-0002-4729-761X","position":5,"is_corresponding":false},{"id":503092,"name":"Lorne J. Hofseth","orcid":"0000-0002-3200-452X","position":6,"is_corresponding":false},{"id":318652,"name":"E. Angela Murphy","orcid":"0000-0002-4803-5822","position":7,"is_corresponding":false},{"id":668994,"name":"Sierra J. McDonald","orcid":"0000-0002-1894-3272","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T01:11:17.288563Z","pmid":"37489869","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}