{"doi":"10.1152/ajpgi.00023.2025","title":"Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing","abstract":"Our results indicate that polyamines are required for maintaining mitochondrial integrity in intestinal epithelial cells. Polyamine depletion led to mitochondrial dysfunction, along with an inhibition of intestinal epithelial renewal and delayed wound healing. Reinforcing mitochondrial activity by Mito-Tempo ameliorated reduced epithelial renewal and delayed healing in polyamine-deficient cells, demonstrating the importance of mitochondrial metabolism in polyamine-regulated mucosal growth and repair after injury.","journal":"American Journal of Physiology-Gastrointestinal and Liver Physiology","year":2025,"id":513860,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1375636,"name":"Ting Chen","orcid":"0000-0002-9723-9020","position":1,"is_corresponding":false},{"id":900345,"name":"Naomi Han","orcid":null,"position":2,"is_corresponding":false},{"id":1375637,"name":"Hongxia Chen","orcid":"0000-0002-2159-3381","position":3,"is_corresponding":false},{"id":293824,"name":"Hee Kyoung Chung","orcid":null,"position":4,"is_corresponding":false},{"id":671371,"name":"Lan Xiao","orcid":"0000-0002-9784-4626","position":5,"is_corresponding":false},{"id":292776,"name":"Jian‐Ying Wang","orcid":"0000-0003-3002-1040","position":6,"is_corresponding":false},{"id":1237617,"name":"Cassandra A. Cairns","orcid":"0000-0002-4364-4418","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:48:23.284782Z","pmid":"40471931","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}