{"doi":"10.1152/ajpendo.1995.268.2.e360","title":"Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis","abstract":"<jats:p>The plasma fluxes of ornithine (Orn), arginine (Arg), and citrulline (Cit) and rate of conversion of labeled ornithine-to-citrulline (QOrn--&gt;Cit) were estimated in six healthy adult men receiving an arginine-rich or arginine-free L-amino acid-based diet, each for 6 days. On day 7 an 8-h (3-h fast, 5-h fed) primed continuous intravenous infusion of L-[guanido-15N,15N] arginine, L-[ureido-13C]citrulline, L-[5,5,2H2]ornithine, and L-[5,5,5-2H3]leucine was conducted. Mean citrulline fluxes (mumol.kg-1.h-1) were 10.4-13.6 for the various conditions and/or diets and remained unchanged (P &gt; 0.05). Arginine flux was lowered (P &lt; 0.01) by 38% for fed state during arginine-free period. Ornithine fluxes for arginine-rich were (P &lt; 0.01) reduced with the arginine-free diet. Rates of QOrn--&gt;Cit declined by 30% (P &lt; .05) during the fed arginine-free period. Short-term restriction in the dietary supply of arginine did not alter the rate of whole body nitric oxide synthesis. One subject showed a very high output of nitrate on arginine-free diet (6 times average for remaining subjects).</jats:p>","journal":"American Journal of Physiology-Endocrinology and Metabolism","year":1995,"id":17581,"datarank":5.530847826563063,"base_score":4.6913478822291435,"endowment":4.6913478822291435,"self_citation_contribution":0.7037021823343717,"citation_network_contribution":4.8271456442286915,"self_endowment_contribution":0.7037021823343717,"citer_contribution":4.8271456442286915,"corpus_percentile":null,"corpus_rank":null,"citation_count":108,"citer_count":104,"citers_with_citation_signal":85,"citers_with_endowment":85,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":125298,"name":"M. 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