{"doi":"10.1152/ajpendo.00435.2020","title":"The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells","abstract":"Endothelial cell insulin resistance is a major contributor to the development of diabetic complications. In this study, we have shown that CITED2, a transcriptional coregulator, inhibits endothelial insulin signaling through the PI3K/Akt pathway via repression of HIF-dependent IRS-2 expression, and that deletion of CITED2 enhances insulin signaling. Thus, CITED2 represents a novel and promising target to improve insulin sensitivity in endothelial cells and prevent vascular complications in diabetes.","journal":"American Journal of Physiology-Endocrinology and Metabolism","year":2021,"id":194847,"datarank":0.545412752362984,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.20002498841387711,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.20002498841387711,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":true,"deposit_databanks":{"figshare":["10.6084/m9.figshare.14516781.v1"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":765411,"name":"Kuangyang Chen","orcid":"0000-0001-5328-4009","position":1,"is_corresponding":false},{"id":374208,"name":"Sam Lockhart","orcid":"0000-0003-2092-4350","position":2,"is_corresponding":false},{"id":765412,"name":"Xuanchun Wang","orcid":"0000-0003-2980-4363","position":3,"is_corresponding":false},{"id":765413,"name":"Christian Rask‐Madsen","orcid":"0000-0002-8548-466X","position":4,"is_corresponding":false},{"id":765410,"name":"Britta Kunkemoeller","orcid":"0000-0003-0709-1577","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:50:03.719152Z","pmid":"34151583","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}