{"doi":"10.1152/ajpcell.01009.2024","title":"Inhibition of mitochondrial fission protein Drp1 ameliorates skeletal myopathy in the D2-mdx model of Duchenne muscular dystrophy","abstract":"The therapeutic potential of targeting mitochondrial dynamics in treating myopathy in Duchenne muscular dystrophy (DMD) remains unknown. This study is the first to target Drp1-mediated mitochondrial fission to alleviate myopathy in DMD. We reported that Mdivi-1, a pharmacological inhibitor targeting Drp1-mediated mitochondrial fission, was effective in reducing muscle damage and improving skeletal muscle strength in D2-mdx mice. These responses were associated with improved mitochondrial morphology and reduced lipid peroxidation.","journal":"American Journal of Physiology-Cell Physiology","year":2025,"id":519729,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1074490,"name":"Nicolas Berger","orcid":"0000-0001-7276-5246","position":1,"is_corresponding":false},{"id":1329366,"name":"Shantel N. Hodge","orcid":null,"position":2,"is_corresponding":false},{"id":1328870,"name":"Atsutaro Fujishiro","orcid":"0009-0002-8193-5280","position":3,"is_corresponding":false},{"id":1074489,"name":"Jared Lourie","orcid":"0009-0009-7169-4816","position":4,"is_corresponding":false},{"id":1329367,"name":"Vrusti Kapadia","orcid":null,"position":5,"is_corresponding":false},{"id":1389257,"name":"Tessa Duzz","orcid":null,"position":6,"is_corresponding":false},{"id":473002,"name":"Melissa A. Linden","orcid":"0000-0002-3152-0864","position":7,"is_corresponding":false},{"id":1328871,"name":"Eunbin Jee","orcid":"0000-0003-3961-2058","position":8,"is_corresponding":false},{"id":625356,"name":"Jonghan Kim","orcid":"0000-0001-8226-7427","position":9,"is_corresponding":false},{"id":237340,"name":"Yuho Kim","orcid":"0000-0001-6038-4358","position":10,"is_corresponding":false},{"id":1074493,"name":"Kai Zou","orcid":"0000-0003-4164-7129","position":11,"is_corresponding":false},{"id":1075161,"name":"H. Grace Rosen","orcid":null,"position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T02:49:23.618703Z","pmid":"40522885","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}