{"doi":"10.1152/ajpcell.00638.2024","title":"Does force depression resulting from shortening against series elasticity contribute to the activation dependence of optimum length?","abstract":"Length-dependent Ca 2+ sensitivity does not fully explain the activation dependence of optimum length ( L 0 ). We demonstrate using an isolated muscle preparation and added series compliance that substantial force depression can arise during an isometric contraction, causing tetanic L 0 to shift to a shorter length. Our findings illustrate that series compliance, via the work and length dependencies of force depression, partially uncouples force generation from myofilament overlap, which ultimately increases the activation (or force) dependence of L 0 .","journal":"American Journal of Physiology-Cell Physiology","year":2024,"id":472847,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1085918,"name":"Natalie C. Holt","orcid":"0000-0003-0006-1279","position":1,"is_corresponding":false},{"id":1085919,"name":"Dean L. Mayfield","orcid":"0000-0003-4036-7117","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":null,"created_at":"2026-07-19T02:05:57.032095Z","pmid":"39726260","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}