{"doi":"10.1152/ajpcell.00555.2023","title":"Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression","abstract":"The calcium-activated chloride channel, TMEM16A, is upregulated in the diabetic vasculature to cause increased vasoconstriction. In this paper, we have uncovered that the TMEM16A gene expression is controlled by a Snail-mediated repressor complex that uncouples with both insulin-dependent and -independent pathways to allow for upregulated arterial protein expression thereby causing vasoconstriction. The paper highlights the effect of short- and long-term glucose-induced dysfunction of an ion channel expression as a causative factor in diabetic vascular disease.","journal":"American Journal of Physiology-Cell Physiology","year":2024,"id":459267,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":962009,"name":"Masuma Akter Brishti","orcid":null,"position":1,"is_corresponding":false},{"id":1060887,"name":"Angelica Karina Bernardelli","orcid":"0000-0001-5203-1966","position":2,"is_corresponding":false},{"id":353065,"name":"Alejandro Mata‐Daboin","orcid":"0000-0003-1831-7842","position":3,"is_corresponding":false},{"id":353069,"name":"Jonathan H. Jaggar","orcid":"0000-0003-1505-3335","position":4,"is_corresponding":false},{"id":353061,"name":"M. Dennis Leo","orcid":"0000-0002-2703-4011","position":5,"is_corresponding":false},{"id":700995,"name":"Somasundaram Raghavan","orcid":"0000-0002-7385-7182","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:03:55.280882Z","pmid":"38581667","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}