{"doi":"10.1152/ajpcell.00413.2024","title":"Bone marrow stromal cells enhance differentiation of acute myeloid leukemia induced by pyrimidine synthesis inhibitors","abstract":"This study is the first to demonstrate that human stromal cell lines and primary mesenchymal stromal cells from patients enhance the in vitro differentiation of acute myeloid leukemia (AML) cells induced by pyrimidine synthesis inhibitors, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr), and brequinar. Furthermore, this is the first report to show that AICAr affects mouse bone marrow stromal cells by activating AMP-activated protein kinase (AMPK) and that human stromal cells are superior to mouse cells for testing the effects of drugs on AML differentiation.","journal":"American Journal of Physiology-Cell Physiology","year":2024,"id":450646,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905798,"name":"Hrvoje Lalić","orcid":"0000-0003-4078-4439","position":1,"is_corresponding":false},{"id":905799,"name":"Vilma Dembitz","orcid":"0000-0002-9463-253X","position":2,"is_corresponding":false},{"id":905796,"name":"Barbara Tomić","orcid":"0000-0002-3705-7372","position":3,"is_corresponding":false},{"id":905800,"name":"Josip Batinić","orcid":"0000-0001-5595-9911","position":4,"is_corresponding":false},{"id":770401,"name":"Radovan Vrḫovac","orcid":"0000-0003-3323-3487","position":5,"is_corresponding":false},{"id":693465,"name":"Antonio Bedalov","orcid":"0000-0002-7373-8255","position":6,"is_corresponding":false},{"id":905801,"name":"Dora Višnjić","orcid":"0000-0003-2207-7191","position":7,"is_corresponding":false},{"id":905797,"name":"Tomislav Smoljo","orcid":"0000-0002-4067-5649","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:02:28.969209Z","pmid":"39279497","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}