{"doi":"10.1152/ajpcell.00339.2023","title":"Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signaling by lncRNA\n                    <i>Tug1</i>\n                    in cardiomyocytes","abstract":"<jats:p>Calcium is essential for signaling, excitation contraction, and energy homeostasis in the heart. Despite this, molecular regulators of these processes are not completely understood. We report that knockdown of lncRNA Tug1 alters the calcium handling transcriptome and increases mitochondrial calcium uniporter expression via a mechanism involving CaMKII. As overexpression of MCU is known to be protective against pathological cardiac remodeling, targeting Tug1 may be a potential strategy for treating cardiovascular disease.</jats:p>","journal":"American Journal of Physiology-Cell Physiology","year":2023,"id":683572,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1308103,"name":"Kate L. 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We report that knockdown of lncRNA Tug1 alters the calcium handling transcriptome and increases mitochondrial calcium uniporter expression via a mechanism involving CaMKII. As overexpression of MCU is known to be protective against pathological cardiac remodeling, targeting Tug1 may be a potential strategy for treating cardiovascular disease.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37721002","pmcid":null,"openalex_id":"https://openalex.org/W4386817499","authors":[],"funders":[{"funder_name":"Deakin University","grant_id":"Faculty of Health Research Capacity Building Grant","title":null},{"funder_name":"National Heart Foundation of Australia","grant_id":"Future Leader Fellowship (102539)","title":null}],"total_grants":2,"fwci":1.3117,"citation_percentile":0.8264561,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00339.2023","host_type":"publisher"},{"url":"https://doi.org/10.1152/ajpcell.00339.2023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37721002","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/23/2023.07.22.550175.full.pdf","host_type":"Unpaywall"}],"fields_of_study":["Cancer-related molecular mechanisms research","RNA Research and Splicing","RNA and protein synthesis mechanisms","Animals","Rats","Calcium","Calcium Signaling","Calcium-Calmodulin-Dependent Protein Kinase Type 2","Mitochondrial Membrane Transport Proteins","Myocytes, Cardiac","RNA, Long Noncoding","Calcium Channels"],"mesh_terms":["Animals","Calcium","Calcium Channels","Calcium Signaling","Myocytes, Cardiac","Mitochondrial Membrane Transport Proteins","Rats","Calcium-Calmodulin-Dependent Protein Kinase Type 2","RNA, Long Noncoding"],"keywords":["CREB","Cell biology","Uniporter","Calcium signaling","Phosphorylation","Gene expression","Calmodulin","Gene knockdown","Chemistry","Mitochondrion","Biology","Signal transduction","Transcription factor","Biochemistry","Cytosol","Gene","Enzyme","Mitochondria","Cardiac","Transcriptome","Noncoding RNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T11:32:32.949947Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}