{"doi":"10.1152/ajpcell.00272.2023","title":"Bacterial lipopolysaccharide inhibits colonic carrier-mediated uptake of thiamin pyrophosphate: roles for TLR4 receptor and NF-κB/P38/JNK signaling pathway","abstract":"This study examined the effect of the bacterial lipopolysaccharide (LPS) on the colonic uptake of thiamin pyrophosphate (TPP), the biologically active form of vitamin B1. Three complementary models were used: in vitro (human NCM460 cells), ex vivo (human colonoids), and in vivo (mice). The results showed LPS to significantly suppress TPP uptake and the expression of its transporter, and that these effects are mediated via the membrane TLR4 receptor, and involve the NF-κB/p38/JNK signaling pathways.","journal":"American Journal of Physiology-Cell Physiology","year":2023,"id":364286,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":863218,"name":"Subrata Sabui","orcid":"0000-0003-1037-8149","position":1,"is_corresponding":false},{"id":307364,"name":"Katherine J. Lee","orcid":"0000-0002-8334-0291","position":2,"is_corresponding":false},{"id":727258,"name":"Alaullah Sheikh","orcid":"0000-0002-2972-6978","position":3,"is_corresponding":false},{"id":388737,"name":"James M. Fleckenstein","orcid":"0000-0002-1148-697X","position":4,"is_corresponding":false},{"id":513673,"name":"Hamid M. Said","orcid":"0000-0003-1016-8547","position":5,"is_corresponding":false},{"id":1119080,"name":"Anthonymuthu Selvaraj","orcid":"0000-0001-7316-1436","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:14:36.728255Z","pmid":"37519229","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}