{"doi":"10.1152/ajpcell.00116.2024","title":"Sex-specific activation of platelet purinergic signaling is key in local cytokine release and phagocytosis in the peritoneal cavity in intra-abdominal sepsis","abstract":"Intra-abdominal sepsis is a challenging complication postabdominal surgery caused by perforations of the gastrointestinal tract where microbes invade the peritoneal cavity. This leads to local cytokine release and immune cell dysfunction. Our data identify platelets as key players in mediating inflammation in intra-abdominal sepsis. We have shown that blocking purinergic signaling in the peritoneal cavity reduced cytokine release and cell-cell interactions differently in males and females, hence a sex-specific strategy to improve intra-abdominal sepsis.","journal":"American Journal of Physiology-Cell Physiology","year":2025,"id":540184,"datarank":0.18443101341608156,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.019639170115865114,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.019639170115865114,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1428032,"name":"Emmanuel Boadi Amoafo","orcid":"0009-0002-6321-3516","position":1,"is_corresponding":false},{"id":1371991,"name":"Ying Kang","orcid":"0000-0001-9963-4318","position":2,"is_corresponding":false},{"id":1428344,"name":"Thomas R. Gustad","orcid":null,"position":3,"is_corresponding":false},{"id":674310,"name":"Glenn Dorsam","orcid":"0000-0001-5902-4347","position":4,"is_corresponding":false},{"id":564362,"name":"Mark R. Frey","orcid":"0000-0002-2561-5402","position":5,"is_corresponding":false},{"id":1001893,"name":"Elisabetta Liverani","orcid":"0000-0001-5540-0456","position":6,"is_corresponding":false},{"id":1428031,"name":"Philomena Entsie","orcid":"0000-0002-4858-8339","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:38.861025Z","pmid":"39854048","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}