{"doi":"10.1148/ryct.220081","title":"Distinguishing Type 1 from Type 2 Myocardial Infarction by Using CT Coronary Angiography","abstract":"Purpose To determine whether quantitative plaque characterization by using CT coronary angiography (CTCA) can discriminate between type 1 and type 2 myocardial infarction. Materials and Methods This was a secondary analysis of two prospective studies (ClinicalTrials.gov registration nos. NCT03338504 [2014–2019] and NCT02284191 [2018–2020]) that performed blinded quantitative plaque analysis on findings from CTCA in participants with type 1 myocardial infarction, type 2 myocardial infarction, and chest pain without myocardial infarction. Logistic regression analyses were performed to identify predictors of type 1 myocardial infarction. Results Overall, 155 participants (mean age, 64 years ± 12 [SD]; 114 men) and 36 participants (mean age, 67 years ± 12; 19 men) had type 1 and type 2 myocardial infarction, respectively, and 136 participants (62 years ± 12; 78 men) had chest pain without myocardial infarction. Participants with type 1 myocardial infarction had greater total (median, 44% [IQR: 35%–50%] vs 35% [IQR: 29%–46%]), noncalcified (39% [IQR: 31%–46%] vs 34% [IQR: 29%–40%]), and low-attenuation (4.15% [IQR: 1.88%–5.79%] vs 1.64% [IQR: 0.89%–2.28%]) plaque burdens (P < .05 for all) than those with type 2. Participants with type 2 myocardial infarction had similar low-attenuation plaque burden to those with chest pain without myocardial infarction (P = .4). Low-attenuation plaque was an independent predictor of type 1 myocardial infarction (adjusted odds ratio, 3.44 [95% CI: 1.84, 6.96]; P < .001), with better discrimination than noncalcified plaque burden and maximal area of coronary stenosis (C statistic, 0.75 [95% CI: 0.67, 0.83] vs 0.62 [95% CI: 0.53, 0.71] and 0.61 [95% CI: 0.51, 0.70] respectively; P ≤ .001 for both). Conclusion Higher low-attenuation coronary plaque burden in patients with type 1 myocardial infarction may help distinguish these patients from those with type 2 myocardial infarction. Keywords: Ischemia/Infarction, CT Angiography, Quantitative CT Clinical trial registration nos. NCT03338504 and NCT02284191 Supplemental material is available for this article. © RSNA, 2022","journal":"Radiology Cardiothoracic Imaging","year":2022,"id":275911,"datarank":0.3883433638711317,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.04295559992202478,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.04295559992202478,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":5,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03338504","NCT02284191"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":945973,"name":"Anda Bularga","orcid":"0000-0002-5530-527X","position":1,"is_corresponding":false},{"id":259166,"name":"Evangelos Tzolos","orcid":"0000-0003-0038-043X","position":2,"is_corresponding":false},{"id":945974,"name":"Andrew R. Chapman","orcid":"0000-0003-1926-5925","position":3,"is_corresponding":false},{"id":842697,"name":"Marwa Daghem","orcid":"0000-0003-1655-2750","position":4,"is_corresponding":false},{"id":945975,"name":"John Hung","orcid":"0000-0002-2269-2947","position":5,"is_corresponding":false},{"id":945976,"name":"Justin Chiong","orcid":"0000-0003-3795-5639","position":6,"is_corresponding":false},{"id":945977,"name":"Caelan Taggart","orcid":"0000-0001-7379-5439","position":7,"is_corresponding":false},{"id":852535,"name":"Ryan Wereski","orcid":"0000-0001-6485-453X","position":8,"is_corresponding":false},{"id":945978,"name":"Alasdair Gray","orcid":"0000-0003-1460-8327","position":9,"is_corresponding":false},{"id":246999,"name":"Marc R. Dweck","orcid":"0000-0001-9847-5917","position":10,"is_corresponding":false},{"id":945979,"name":"Carl Roobottom","orcid":"0000-0001-5066-7645","position":11,"is_corresponding":false},{"id":537882,"name":"Nick Curzen","orcid":"0000-0001-9651-7829","position":12,"is_corresponding":false},{"id":945980,"name":"Attila Kardos","orcid":"0000-0002-0231-7605","position":13,"is_corresponding":false},{"id":945981,"name":"D Felmeden","orcid":"0000-0003-3564-5055","position":14,"is_corresponding":false},{"id":655688,"name":"Nicholas L. Mills","orcid":"0000-0003-0533-7991","position":15,"is_corresponding":false},{"id":259173,"name":"Piotr J. Slomka","orcid":"0000-0002-6110-938X","position":16,"is_corresponding":false},{"id":259172,"name":"David E. Newby","orcid":"0000-0001-7971-4628","position":17,"is_corresponding":false},{"id":259171,"name":"Damini Dey","orcid":"0000-0003-2236-6970","position":18,"is_corresponding":false},{"id":235799,"name":"Michelle C. Williams","orcid":"0000-0003-3556-2428","position":19,"is_corresponding":false},{"id":352742,"name":"Mohammed N. Meah","orcid":"0000-0002-0806-9972","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T00:28:26.545826Z","pmid":"36339063","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}