{"doi":"10.1148/ryct.2020200134","title":"Accelerated 3D Left Atrial Late Gadolinium Enhancement in Patients with Atrial Fibrillation at 1.5 T: Technical Development","abstract":"Purpose To develop an accelerated three-dimensional (3D) late gadolinium enhancement (LGE) pulse sequence using balanced steady-state free precession readout with stack-of-stars k-space sampling and extra motion-state golden-angle radial sparse parallel (XD-GRASP) reconstruction and test the performance for detecting atrial scar and fibrosis in patients with atrial fibrillation (AF). Materials and Methods Twenty-five patients with AF (20 paroxysmal and five persistent; 65 years ± 7 [standard deviation]; 18 men) were imaged at 1.5 T using the proposed LGE sequence with 1.3 mm × 1.3 mm × 2-mm spatial resolution and predictable imaging time. The resulting images were compared with historic images of 25 patients with AF (18 paroxysmal and seven persistent; 67 years ± 10; 14 men) obtained using a reference 3D left atrial (LA) LGE sequence with 1.3 mm × 1.3 mm × 2.5-mm spatial resolution. Two readers visually graded the 3D LGE images (conspicuity, artifact, noise) on a five-point Likert scale (1 = worst, 3 = acceptable, 5 = best), in which the summed visual score (SVS) of 9 or greater was defined as clinically acceptable. Appropriate statistical analyses (Cohen κ coefficient, Mann-Whitney U test, t tests, and intraclass correlation) were performed, where a P value < .05 was considered significant. Results Mean imaging time was significantly shorter (P < .01) for the proposed pulse sequence (5.9 minutes ± 1.3) than for the reference pulse sequence (10.6 minutes ± 2). Median SVS was significantly higher (P < .01) for the proposed (SVS = 11) than reference (SVS = 9.5) 3D LA LGE images. Interrater reproducibility in visual scores was higher for the proposed (κ = 0.78–1) than reference 3D LA LGE (κ = 0.44–0.75). Intrareader repeatability in fibrosis quantification was higher for the reference cohort (intraclass correlation coefficient [ICC] = 0.94) than the prospective cohort (ICC = 0.79). Conclusion The proposed 3D LA LGE method produced clinically acceptable image quality with 1.5 mm × 1.5 mm × 2-mm nominal spatial resolution and 6-minute predictable imaging time for quantification of LA scar and fibrosis in patients with AF. Supplemental material is available for this article. Keywords: Adults, Cardiac, Left Atrium, MR-Imaging, Pulmonary Vein Isolation or Ablation (PVI), Technology Assessment © RSNA, 2020","journal":"Radiology Cardiothoracic Imaging","year":2020,"id":90386,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9664,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":317793,"name":"Hassan Haji‐Valizadeh","orcid":"0000-0002-7652-1748","position":1,"is_corresponding":false},{"id":241146,"name":"Daniel Lee","orcid":"0000-0001-9447-4175","position":2,"is_corresponding":false},{"id":345284,"name":"Ryan Avery","orcid":"0000-0002-7913-0574","position":3,"is_corresponding":false},{"id":455994,"name":"Brent D. Wilson","orcid":null,"position":4,"is_corresponding":false},{"id":455444,"name":"Mark Ibrahim","orcid":"0000-0003-4972-9620","position":5,"is_corresponding":false},{"id":319743,"name":"Michael Markl","orcid":"0000-0002-7686-1128","position":6,"is_corresponding":false},{"id":342551,"name":"Rod Passman","orcid":"0000-0001-8718-1534","position":7,"is_corresponding":false},{"id":455445,"name":"Eugene Kholmovski","orcid":"0000-0002-3271-7247","position":8,"is_corresponding":false},{"id":326671,"name":"Daniel Kim","orcid":"0000-0003-2660-8973","position":9,"is_corresponding":false},{"id":342547,"name":"Suvai Gunasekaran","orcid":"0000-0001-6898-5211","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:02:48.683291Z","pmid":"33154994","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}