{"doi":"10.1148/ryai.230277","title":"Anatomy-specific Progression Classification in Chest Radiographs via Weakly Supervised Learning","abstract":"Purpose To develop a machine learning approach for classifying disease progression in chest radiographs using weak labels automatically derived from radiology reports. Materials and Methods In this retrospective study, a twin neural network was developed to classify anatomy-specific disease progression into four categories: improved, unchanged, worsened, and new. A two-step weakly supervised learning approach was employed, pretraining the model on 243 008 frontal chest radiographs from 63 877 patients (mean age, 51.7 years ± 17.0 [SD]; 34 813 [55%] female) included in the MIMIC-CXR database and fine-tuning it on the subset with progression labels derived from consecutive studies. Model performance was evaluated for six pathologic observations on test datasets of unseen patients from the MIMIC-CXR database. Area under the receiver operating characteristic (AUC) analysis was used to evaluate classification performance. The algorithm is also capable of generating bounding-box predictions to localize areas of new progression. Recall, precision, and mean average precision were used to evaluate the new progression localization. One-tailed paired t tests were used to assess statistical significance. Results The model outperformed most baselines in progression classification, achieving macro AUC scores of 0.72 ± 0.004 for atelectasis, 0.75 ± 0.007 for consolidation, 0.76 ± 0.017 for edema, 0.81 ± 0.006 for effusion, 0.7 ± 0.032 for pneumonia, and 0.69 ± 0.01 for pneumothorax. For new observation localization, the model achieved mean average precision scores of 0.25 ± 0.03 for atelectasis, 0.34 ± 0.03 for consolidation, 0.33 ± 0.03 for edema, and 0.31 ± 0.03 for pneumothorax. Conclusion Disease progression classification models were developed on a large chest radiograph dataset, which can be used to monitor interval changes and detect new pathologic conditions on chest radiographs. Keywords: Prognosis, Unsupervised Learning, Transfer Learning, Convolutional Neural Network (CNN), Emergency Radiology, Named Entity Recognition Supplemental material is available for this article. © RSNA, 2024 See also commentary by Alves and Venkadesh in this issue.","journal":"Radiology Artificial Intelligence","year":2024,"id":478948,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":383400,"name":"Shantanu Ghosh","orcid":"0000-0003-4085-541X","position":1,"is_corresponding":false},{"id":1318259,"name":"Zhexiong Liu","orcid":null,"position":2,"is_corresponding":false},{"id":462637,"name":"Christopher Deible","orcid":null,"position":3,"is_corresponding":false},{"id":823523,"name":"Clare B. Poynton","orcid":"0000-0003-3825-7664","position":4,"is_corresponding":false},{"id":59219,"name":"Kayhan Batmanghelich","orcid":"0000-0001-9893-9136","position":5,"is_corresponding":false},{"id":805459,"name":"Ke Yu","orcid":"0000-0001-9882-5729","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:06:50.355747Z","pmid":"39046325","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}