{"doi":"10.1148/radiol.212403","title":"Association between Abdominal CT Measurements of Body Composition before Deceased Donor Liver Transplant with Posttransplant Outcomes","abstract":"Background Pre–liver transplant (LT) sarcopenia is associated with poor survival. Methods exist for measuring body composition with use of CT scans; however, it is unclear which components best predict post-LT outcomes. Purpose To quantify the association between abdominal CT–based body composition measurements and post-LT mortality in a large North American cohort. Materials and Methods This was a retrospective cohort of adult first-time deceased-donor LT recipients from 2009 to 2018 who underwent pre-LT abdominal CT scans, including at the L3 vertebral level, at Johns Hopkins Hospital. Measurements included sarcopenia (skeletal muscle index [SMI] <50 in men and <39 in women), sarcopenic obesity, myosteatosis (skeletal muscle CT attenuation <41 mean HU for body mass index [BMI] <25 and <33 mean HU for BMI ≥25), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT ratio. Covariates in the adjusted models were selected with use of least absolute shrinkage and selection operator regression with lambda chosen by means of 10-fold cross-validation. Cox proportional hazards models were used to quantify associations with post-LT mortality. Model discrimination was quantified using the Harrell C-statistic. Results A total of 454 recipients (median age, 57 years [IQR, 50–62 years]; 294 men) were evaluated. In the adjusted model, pre-LT sarcopenia was associated with a higher hazard ratio (HR) of post-LT mortality (HR, 1.6 [95% CI: 1.1, 2.4]; C-statistic, 0.64; P = .02). SMI was significantly negatively associated with survival after adjustment for covariates. There was no evidence that myosteatosis was associated with mortality (HR, 1.3 [95% CI: 0.86, 2.1]; C-statistic, 0.64; P = .21). There was no evidence that BMI (HR, 1.2 [95% CI: 0.95, 1.4]), VAT (HR, 1.0 [95% CI: 0.98, 1.1]), SAT (HR, 1.0 [95% CI: 0.97, 1.0]), and VAT/SAT ratio (HR, 1.1 [95% CI: 0.90, 1.4]) were associated with mortality (P = .15–.77). Conclusions Sarcopenia, as assessed on routine pre–liver transplant (LT) abdominal CT scans, was the only factor significantly associated with post-LT mortality. © RSNA, 2022 See also the editorial by Ruehm in this issue.","journal":"Radiology","year":2022,"id":240565,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7647,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":868554,"name":"Yi Liu","orcid":"0000-0003-1640-3501","position":1,"is_corresponding":false},{"id":329413,"name":"Kyle R. Jackson","orcid":"0000-0002-8135-5377","position":2,"is_corresponding":false},{"id":72290,"name":"Jennifer D. Motter","orcid":"0000-0003-1750-0119","position":3,"is_corresponding":false},{"id":329410,"name":"Brian J. Boyarsky","orcid":"0000-0001-6902-9854","position":4,"is_corresponding":false},{"id":868555,"name":"Muhammad Latif","orcid":"0000-0003-1967-2360","position":5,"is_corresponding":false},{"id":800119,"name":"Frank Yuan","orcid":"0000-0003-4320-1219","position":6,"is_corresponding":false},{"id":800120,"name":"Adham Khalil","orcid":"0000-0002-0582-8160","position":7,"is_corresponding":false},{"id":868556,"name":"Elizabeth A. King","orcid":"0000-0002-0844-3602","position":8,"is_corresponding":false},{"id":62892,"name":"Atif Zaheer","orcid":"0000-0002-4824-6654","position":9,"is_corresponding":false},{"id":104554,"name":"Ronald M. Summers","orcid":"0000-0001-8081-7376","position":10,"is_corresponding":false},{"id":257567,"name":"Dorry L. Segev","orcid":"0000-0002-1924-4801","position":11,"is_corresponding":false},{"id":257566,"name":"Mara McAdams‐DeMarco","orcid":"0000-0003-3013-925X","position":12,"is_corresponding":false},{"id":378700,"name":"Clifford R. Weiss","orcid":"0000-0003-2180-1731","position":13,"is_corresponding":false},{"id":48690,"name":"Omid Shafaat","orcid":"0000-0001-8793-7901","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T00:22:51.435773Z","pmid":"36283115","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}