{"doi":"10.1148/radiol.12120226","title":"Hypervascular Hepatocellular Carcinoma: Correlation between Biologic Features and Signal Intensity on Gadoxetic Acid–enhanced MR Images","abstract":null,"journal":"Radiology","year":2012,"id":672328,"datarank":0.7324202883879557,"base_score":4.882801922586371,"endowment":4.882801922586371,"self_citation_contribution":0.7324202883879557,"citation_network_contribution":0.0,"self_endowment_contribution":0.7324202883879557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":131,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1681651,"name":"Osamu Matsui","orcid":"0000-0003-4204-5269","position":1,"is_corresponding":false},{"id":1748733,"name":"Norihide Yoneda","orcid":null,"position":2,"is_corresponding":false},{"id":1681650,"name":"Kazuto Kozaka","orcid":"0000-0002-7349-7623","position":3,"is_corresponding":false},{"id":318487,"name":"Satoshi Kobayashi","orcid":"0000-0002-2535-6586","position":4,"is_corresponding":false},{"id":1748732,"name":"Wataru Koda","orcid":null,"position":5,"is_corresponding":false},{"id":1748731,"name":"Toshifumi Gabata","orcid":null,"position":6,"is_corresponding":false},{"id":135068,"name":"Tatsuya Yamashita","orcid":null,"position":7,"is_corresponding":false},{"id":597157,"name":"Shuichi Kaneko","orcid":"0000-0001-7113-3319","position":8,"is_corresponding":false},{"id":1748734,"name":"Yasuni Nakanuma","orcid":null,"position":9,"is_corresponding":false},{"id":1756615,"name":"Ryuichi Kita","orcid":null,"position":10,"is_corresponding":false},{"id":1756616,"name":"Shigeki Arii","orcid":null,"position":11,"is_corresponding":false},{"id":1162504,"name":"Azusa Kitao","orcid":"0000-0002-5597-9346","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hypervascular Hepatocellular Carcinoma: Correlation between Biologic Features and Signal Intensity on Gadoxetic Acid–enhanced MR Images","abstract":"PURPOSE: To analyze the correlation among biologic features, tumor marker production, and signal intensity at gadoxetic acid-enhanced MR imaging in hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Institutional ethics committee approval and informed consent were obtained for this retrospective study. From April 2008 to September 2011, 180 surgically resected HCCs in 180 patients (age, 65.0 years ± 10.3 [range, 34-83 years]; 138 men, 42 women) were classified as either hypointense (n = 158) or hyperintense (n = 22) compared with the signal intensity of the background liver on hepatobiliary phase gadoxetic acid-enhanced MR images. Pathologic features were analyzed and a fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) production were compared by means of serum analysis and immunohistochemical staining. Recurrence and survival rates were also evaluated. The Mann-Whitney and Pearson correlation tests were used for statistical analysis. RESULTS: The grade of differentiation was higher (P = .028) and portal vein invasion was less frequent in hyperintense HCCs (13.6%) than in hypointense HCCs (36.7%) (P = .039). The serum levels of AFP, Lens culinaris agglutinin reactive fraction of AFP, and PIVKA-II were lower in hyperintense than in hypointense HCCs (P = .003, .004, and .026, respectively). Immunohistochemical AFP and PIVKA-II expression were lower in hyperintense than in hypointense HCCs (both P < .001). The recurrence rate was lower in hyperintense than in hypointense HCCs (P = .039). CONCLUSION: The results suggest that hyperintense HCCs on gadoxetic acid-enhanced MR images are less aggressive than hypointense HCCs. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120226/-/DC1.","is_dataset_classified":null,"base_score":4.882801922586371,"endowment":4.882801922586371,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23175543","pmcid":"PMC5375624","openalex_id":"https://openalex.org/W2163639981","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"UL1 RR025758","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"1 UL1 RR 025758-01","title":null}],"total_grants":2,"fwci":4.621,"citation_percentile":0.95700787,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":13},{"year":2015,"count":18},{"year":2016,"count":7},{"year":2017,"count":10},{"year":2018,"count":11},{"year":2019,"count":12},{"year":2020,"count":13},{"year":2021,"count":17},{"year":2022,"count":6},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":8},{"year":2026,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://pubs.rsna.org/doi/pdf/10.1148/radiol.12120226","host_type":"publisher"},{"url":"https://doi.org/10.1148/radiol.12120226","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23175543","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5375624","host_type":"repository"}],"fields_of_study":["Hepatocellular Carcinoma Treatment and Prognosis","MRI in cancer diagnosis","Cancer, Hypoxia, and Metabolism"],"mesh_terms":["Solute Carrier Organic Anion Transporter Family Member 1B3","Adult","Aged","Aged, 80 and over","alpha-Fetoproteins","Contrast Media","Female","Carcinoma, Hepatocellular","Humans","Immunohistochemistry","Liver Neoplasms","Magnetic Resonance Imaging","Male","Middle Aged","Neoplasm Invasiveness","Neoplasm Recurrence, Local","Protein Precursors","Prothrombin","Retrospective Studies","Biomarkers, Tumor","Biomarkers","Survival Rate","Gadolinium DTPA","Organic Anion Transporters, Sodium-Independent"],"keywords":["Gadoxetic acid","HCCS","Medicine","Hepatocellular carcinoma","Magnetic resonance imaging","Radiology","Immunohistochemistry","Gastroenterology","Pathology","Internal medicine","Gadolinium DTPA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T08:40:52.361873Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}