{"doi":"10.1148/radiol.10092214","title":"Hepatocellular Carcinoma: Signal Intensity at Gadoxetic Acid–enhanced MR Imaging—Correlation with Molecular Transporters and Histopathologic Features","abstract":null,"journal":"Radiology","year":2010,"id":669568,"datarank":0.8747823715925277,"base_score":5.831882477283517,"endowment":5.831882477283517,"self_citation_contribution":0.8747823715925277,"citation_network_contribution":0.0,"self_endowment_contribution":0.8747823715925277,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":340,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1016903,"name":"Yoh Zen","orcid":"0000-0001-8370-6508","position":1,"is_corresponding":false},{"id":1681651,"name":"Osamu Matsui","orcid":"0000-0003-4204-5269","position":2,"is_corresponding":false},{"id":1748731,"name":"Toshifumi Gabata","orcid":null,"position":3,"is_corresponding":false},{"id":318487,"name":"Satoshi Kobayashi","orcid":"0000-0002-2535-6586","position":4,"is_corresponding":false},{"id":1748732,"name":"Wataru Koda","orcid":null,"position":5,"is_corresponding":false},{"id":1681650,"name":"Kazuto Kozaka","orcid":"0000-0002-7349-7623","position":6,"is_corresponding":false},{"id":1748733,"name":"Norihide Yoneda","orcid":null,"position":7,"is_corresponding":false},{"id":135068,"name":"Tatsuya Yamashita","orcid":null,"position":8,"is_corresponding":false},{"id":835940,"name":"Shuichi Kaneko","orcid":"0000-0002-3137-8183","position":9,"is_corresponding":false},{"id":1748734,"name":"Yasuni Nakanuma","orcid":null,"position":10,"is_corresponding":false},{"id":1162504,"name":"Azusa Kitao","orcid":"0000-0002-5597-9346","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hepatocellular Carcinoma: Signal Intensity at Gadoxetic Acid–enhanced MR Imaging—Correlation with Molecular Transporters and Histopathologic Features","abstract":"PURPOSE: To analyze the correlation between signal intensity in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging and the expression of hepatocyte transporters with histopathologic features in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Institutional ethics committee approval and informed consent were obtained. Forty surgically resected HCCs were classified as hypointense (n = 32) or iso- or hyperintense (n = 8) on the basis of findings in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging. The following were compared between hypointense and iso- or hyperintense HCCs: the time-signal intensity curves at gadoxetic acid-enhanced MR imaging, the expression levels of seven transporters (four organic anion-transporting polypeptides [OATPs] and three multidrug-resistant proteins [MRPs]) at polymerase chain reaction (PCR) (for 22 nodules), results of immunostaining of OATP8, and histologic features. Statistical analysis (unpaired t test, Mann-Whitney test, chi(2) test, and Fisher exact test) was performed for each result. RESULTS: On the time-signal intensity curves, hypointense HCCs showed a decreasing pattern, whereas iso- or hyperintense HCCs showed an increasing pattern after the dynamic phase. PCR revealed that expression of OATP8 (an uptake transporter) in hypointense HCCs was lower and that in iso- or hyperintense HCCs was higher than in background liver (P < .001). The expression level of MRP3 (a sinusoidal export transporter) showed a similar trend to that of OATP8 (P < .001). Immunostaining revealed that OATP8 expression was weak in hypointense HCCs, whereas it was sustained in iso- or hyperintense HCCs (P < .001). At histologic examination, a pseudoglandular proliferation pattern with bile plugs was more commonly observed in iso- or hyperintense HCCs than in hypointense HCCs (P = .01 for proliferation patterns and P = .006 for bile plugs). CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.","is_dataset_classified":null,"base_score":5.831882477283517,"endowment":5.831882477283517,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20663969","pmcid":null,"openalex_id":"https://openalex.org/W1979185563","authors":[],"funders":[],"total_grants":0,"fwci":13.283,"citation_percentile":0.99413353,"influential_citations":0,"citation_trend":[{"year":2012,"count":37},{"year":2013,"count":35},{"year":2014,"count":44},{"year":2015,"count":22},{"year":2016,"count":23},{"year":2017,"count":16},{"year":2018,"count":24},{"year":2019,"count":20},{"year":2020,"count":21},{"year":2021,"count":28},{"year":2022,"count":13},{"year":2023,"count":10},{"year":2024,"count":10},{"year":2025,"count":7},{"year":2026,"count":4}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://pubs.rsna.org/doi/pdf/10.1148/radiol.10092214","host_type":"publisher"},{"url":"https://doi.org/10.1148/radiol.10092214","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20663969","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","MRI in cancer diagnosis","Hepatocellular Carcinoma Treatment and Prognosis","Adult","Aged","Aged, 80 and over","Carcinoma, Hepatocellular","Chi-Square Distribution","Contrast Media","Female","Gadolinium DTPA","Humans","Immunohistochemistry","Liver Neoplasms","Magnetic Resonance Imaging","Male","Middle Aged","ATP-Binding Cassette, Sub-Family C Proteins","Organic Anion Transporters, Sodium-Independent","RNA, Messenger","Retrospective Studies","Reverse Transcriptase Polymerase Chain Reaction","Solute Carrier Organic Anion Transporter Family Member 1B3","Statistics, Nonparametric"],"mesh_terms":["Solute Carrier Organic Anion Transporter Family Member 1B3","Adult","Aged","Aged, 80 and over","Contrast Media","Female","Carcinoma, Hepatocellular","Humans","Immunohistochemistry","Liver Neoplasms","Magnetic Resonance Imaging","Male","Middle Aged","Retrospective Studies","RNA, Messenger","Chi-Square Distribution","Statistics, Nonparametric","Gadolinium DTPA","Reverse Transcriptase Polymerase Chain Reaction","Multidrug Resistance-Associated Proteins","ATP-Binding Cassette, Sub-Family C Proteins","Organic Anion Transporters, Sodium-Independent"],"keywords":["Gadoxetic acid","HCCS","Medicine","Hepatocellular carcinoma","Immunostaining","Magnetic resonance imaging","Organic anion transporter 1","Pathology","Radiology","Immunohistochemistry","Transporter","Cancer research","Biology","Gene","Gadolinium DTPA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-14T23:48:48.600306Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}