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Viral infection and cellular stresses also affect eIF4F function. The recent determination of the structure of eIF4E at atomic resolution has provided insight about how translation is initiated and regulated. Evidence suggests that eIF4F is also implicated in malignancy and apoptosis.</jats:p>","journal":"Annual Review of Biochemistry","year":1999,"id":20995,"datarank":17.271991676316535,"base_score":7.6544432264701125,"endowment":7.6544432264701125,"self_citation_contribution":1.148166483970517,"citation_network_contribution":16.12382519234602,"self_endowment_contribution":1.148166483970517,"citer_contribution":16.12382519234602,"corpus_percentile":null,"corpus_rank":null,"citation_count":2109,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":12,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":136831,"name":"Brian Raught","orcid":null,"position":1,"is_corresponding":false},{"id":17875,"name":"Nahum 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Infections and Immunology Research","RNA and protein synthesis mechanisms","RNA Research and Splicing","Biology","Medicine","Amino Acid Sequence","Cell Division","Eukaryotic Initiation Factor-4F","Molecular Sequence Data","Peptide Initiation Factors","Poly A","Protein Biosynthesis","RNA, Messenger","Ribosomes","Sequence Homology, Amino Acid"],"mesh_terms":["Amino Acid Sequence","Cell Division","Molecular Sequence Data","Peptide Initiation Factors","Poly A","Ribosomes","RNA, Messenger","Protein Biosynthesis","Sequence Homology, Amino Acid","Eukaryotic Initiation Factor-4F"],"keywords":["EIF4G","EIF4E","eIF4A","Initiation factor","Eukaryotic initiation factor","Cell biology","Biology","Messenger RNA","Translational regulation","Internal ribosome entry site","Translation (biology)","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24439424.v1","title":"Additional file 1 of Translatome analysis of 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