{"doi":"10.1145/3765612.3767209","title":"Privacy-Preserving Collaborative Population Stratification with Dynamic Algorithm and Hyperparameter Selection","abstract":"We present a privacy-preserving selection layer for collaborative population stratification under ϵ;-local differential privacy (LDP). Rather than fixing a single pipeline (e.g., PCA+K-Means with preset K), our framework lets parties choose among three DP pipelines: PCA→Noise, Noise→PCA, and Noise-Only, according to their resources, and has an honest-but-curious server aggregate only DP shares to automatically select the clustering algorithm (K-Means, GMM, or Hierarchical) and K that maximize internal metrics (Silhouette, Calinski-Harabasz, Davies-Bouldin). Because selection operates on DP data, it adds no further privacy loss. On openSNP (942 samples, 28,396 SNPs), the PCA-augmented pipelines yield higher utility and substantially lower communication and runtime than Noise-Only, and the recommended configuration consistently outperforms fixed baselines. Membership-inference attack power remains markedly lower for PCA-based pipelines across privacy budgets ϵ;. In this paper, experiments are limited to two collaborating parties; extensions to multi-site collaboration are left for future work.","journal":"PubMed","year":2025,"id":584827,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":783759,"name":"Lynette Hammond Gerido","orcid":"0000-0003-2243-6203","position":1,"is_corresponding":false},{"id":430881,"name":"Erman Ayday","orcid":"0000-0003-3383-1081","position":2,"is_corresponding":false},{"id":1337824,"name":"Maryam Ghasemian","orcid":"0009-0000-1078-3414","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":null,"created_at":"2026-07-19T02:59:16.166424Z","pmid":"41960139","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}