{"doi":"10.1145/2245276.2231995","title":"Computing gene functional similarity using combined graphs","abstract":null,"journal":"Proceedings of the 27th Annual ACM Symposium on Applied Computing","year":2012,"id":605989,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555476,"name":"Hisham Al-Mubaid","orcid":null,"position":1,"is_corresponding":false},{"id":1555477,"name":"Said Bettayeb","orcid":null,"position":2,"is_corresponding":false},{"id":1555475,"name":"Anurag Nagar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Computing gene functional similarity using combined graphs","abstract":"The Gene Ontology has been used extensively for measuring the functional similarity among genes of various organisms. All the existing gene similarity methods use either molecular function or biological process taxonomies in computing gene similarity. In this paper, we apply an algorithm for combining graphs to connect the molecular function (F) and biological process (P) taxonomies into one FP taxonomy graph. We then measure the functional similarity of two genes using the resulting FP graph with path length function. The two aspects of GO, molecular function and biological process, are combined by connecting F nodes with P nodes using gene ontology annotation, GOA, databases. By combining two GO graphs, we can have more comprehensive way to explore the functional relationships between genes. We conducted the evaluation on a dataset of OMIM disease phenotypes to estimate the similarity of disease proteins from various diseases.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W2122634659","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.acm.org/publications/policies/copyright_policy#Background","oa_locations":[{"url":"https://dl.acm.org/doi/10.1145/2245276.2231995","host_type":"publisher"},{"url":"https://dl.acm.org/doi/pdf/10.1145/2245276.2231995","host_type":"publisher"},{"url":"https://doi.org/10.1145/2245276.2231995","host_type":""},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.297.4131","host_type":""}],"fields_of_study":["Bioinformatics and Genomic Networks","Biomedical Text Mining and Ontologies","Gene expression and cancer classification"],"mesh_terms":[],"keywords":["Gene ontology","Computer science","Similarity (geometry)","Gene Annotation","Semantic similarity","Graph","Annotation","Gene","Function (biology)","Ontology","Computational biology","Theoretical computer science","Data mining","Information retrieval","Artificial intelligence","Biology","Genome","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:40:17.747767Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}