{"doi":"10.1142/s0218957797000128","title":"Clinical Relevance of the SYT-SSX Fusion Gene in Synovial Sarcoma","abstract":"<jats:p> Recent molecular analyses have reported that the specific translocation t(X;18) (p11.2;q11.2) in synovial sarcoma induces the fusion of the SYT gene on chromosome 18 to either of two duplicated genes on chromosome X, SSX1 or SSX2. As a result, two types of fusion genes SYT-SSX1 and SYT-SSX2, whose products play major roles in tumorigenesis, are formed. However, the precise function of the fusion genes is still unclear. </jats:p><jats:p> To determine clinical relevance of the SYT-SSX fusion genes, we analyzed the fusion transcripts in 13 synovial sarcomas by reverse transcription-polymerase chain reaction (RT-PCR) and also determined the subtype by restriction enzyme assay. These molecular results were compared with certain clinical features of the tumors. </jats:p><jats:p> The SYT-SSX fusion transcript was detected in the majority of the cases (11 / 13) with synovial sarcoma, suggesting that it is a useful diagnostic marker. The subtype analysis showed that only the recurrent tumors expressed SYT-SSX2. This may indicate that there are some biological differences between the two subtypes, such as transforming activity. On this basis, SYT-SSX2 may correlate with the progressive character of this tumor and could be a predictor of prognosis. </jats:p>","journal":"Journal of Musculoskeletal Research","year":1997,"id":680110,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1776976,"name":"N. Araki","orcid":null,"position":1,"is_corresponding":false},{"id":210476,"name":"H. Fukuda","orcid":null,"position":2,"is_corresponding":false},{"id":1776978,"name":"I. Kudawara","orcid":null,"position":3,"is_corresponding":false},{"id":1776979,"name":"H. Yoshikawa","orcid":null,"position":4,"is_corresponding":false},{"id":1776981,"name":"A. Uchida","orcid":null,"position":5,"is_corresponding":false},{"id":1583912,"name":"T. Ochi","orcid":null,"position":6,"is_corresponding":false},{"id":204950,"name":"N. Hashimoto","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical Relevance of the SYT-SSX Fusion Gene in Synovial Sarcoma","abstract":"<jats:p> Recent molecular analyses have reported that the specific translocation t(X;18) (p11.2;q11.2) in synovial sarcoma induces the fusion of the SYT gene on chromosome 18 to either of two duplicated genes on chromosome X, SSX1 or SSX2. As a result, two types of fusion genes SYT-SSX1 and SYT-SSX2, whose products play major roles in tumorigenesis, are formed. However, the precise function of the fusion genes is still unclear. </jats:p><jats:p> To determine clinical relevance of the SYT-SSX fusion genes, we analyzed the fusion transcripts in 13 synovial sarcomas by reverse transcription-polymerase chain reaction (RT-PCR) and also determined the subtype by restriction enzyme assay. These molecular results were compared with certain clinical features of the tumors. </jats:p><jats:p> The SYT-SSX fusion transcript was detected in the majority of the cases (11 / 13) with synovial sarcoma, suggesting that it is a useful diagnostic marker. The subtype analysis showed that only the recurrent tumors expressed SYT-SSX2. This may indicate that there are some biological differences between the two subtypes, such as transforming activity. On this basis, SYT-SSX2 may correlate with the progressive character of this tumor and could be a predictor of prognosis. </jats:p>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W2043822476","authors":[],"funders":[],"total_grants":0,"fwci":0.6085,"citation_percentile":0.69067064,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.worldscientific.com/doi/pdf/10.1142/S0218957797000128","host_type":"publisher"},{"url":"https://doi.org/10.1142/s0218957797000128","host_type":"journal"}],"fields_of_study":["Sarcoma Diagnosis and Treatment","Musculoskeletal synovial abnormalities and treatments"],"mesh_terms":[],"keywords":["Synovial sarcoma","Fusion gene","Chromosomal translocation","Gene","Carcinogenesis","Biology","Cancer research","Fusion transcript","Reverse transcription polymerase chain reaction","Clinical significance","Molecular biology","Sarcoma","Genetics","Messenger RNA","Pathology","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T14:24:49.960859Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}