{"doi":"10.1139/y67-006","title":"HOMOVANILLIC ACID AND DIHYDROXYPHENYLACETIC ACID IN THE STRIATUM OF MONKEYS WITH BRAIN LESIONS","abstract":"<jats:p> Lesions were placed in the left ventromedial tegmental area of the brains of nine monkeys (Macaca mulatto). After 1–4 months, the brains were removed, and the striatum was dissected and prepared for chemical analysis. In seven animals in which the lesion was strictly unilateral, the striatal dopamine was very much reduced below the level found on the intact side of the brain. In the two monkeys in which the lesion impinged on the right side of the brain, the concentration of dopamine was reduced on both sides. Homovanillic acid and 3,4-dihydroxyphenylacetic acid, metabolic derivatives of dopamine, were measured in the left and right striata of four and five monkeys respectively. Both compounds were present at subnormal concentrations on the side of the lesion. The concentration of homovanillic acid did not fall to as great an extent as did that of dopamine. These results are discussed in relation to data reported by others in regard to (a) animals treated with tranquilizing drugs, and (b) brains of patients who died with Parkinson's disease. </jats:p>","journal":"Canadian Journal of Physiology and Pharmacology","year":1967,"id":679822,"datarank":0.62147020895873,"base_score":4.143134726391533,"endowment":4.143134726391533,"self_citation_contribution":0.62147020895873,"citation_network_contribution":0.0,"self_endowment_contribution":0.62147020895873,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":62,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1776253,"name":"L. 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In the two monkeys in which the lesion impinged on the right side of the brain, the concentration of dopamine was reduced on both sides. Homovanillic acid and 3,4-dihydroxyphenylacetic acid, metabolic derivatives of dopamine, were measured in the left and right striata of four and five monkeys respectively. Both compounds were present at subnormal concentrations on the side of the lesion. The concentration of homovanillic acid did not fall to as great an extent as did that of dopamine. These results are discussed in relation to data reported by others in regard to (a) animals treated with tranquilizing drugs, and (b) brains of patients who died with Parkinson's disease. </jats:p>","is_dataset_classified":null,"base_score":4.143134726391533,"endowment":4.143134726391533,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4961824","pmcid":null,"openalex_id":"https://openalex.org/W2152718734","authors":[],"funders":[],"total_grants":0,"fwci":8.3312,"citation_percentile":0.97398699,"influential_citations":0,"citation_trend":[{"year":2012,"count":1}],"oa_status":"closed","license":"http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining","oa_locations":[{"url":"http://www.nrcresearchpress.com/doi/pdf/10.1139/y67-006","host_type":"publisher"},{"url":"https://doi.org/10.1139/y67-006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4961824","host_type":"repository"}],"fields_of_study":["Parkinson's Disease Mechanisms and Treatments","Neuroscience and Neuropharmacology Research","Neurological disorders and treatments","Animals","Basal Ganglia","Brain","Brain Chemistry","Chromatography, Ion Exchange","Dihydroxyphenylalanine","Dopamine","Flavoring Agents","Haplorhini","Phenylacetates"],"mesh_terms":["Animals","Haplorhini","Basal Ganglia","Brain","Brain Chemistry","Chromatography, Ion Exchange","Dihydroxyphenylalanine","Dopamine","Flavoring Agents","Phenylacetates"],"keywords":["Homovanillic acid","Dopamine","Lesion","Striatum","3,4-Dihydroxyphenylacetic acid","Endocrinology","Internal medicine","Medicine","Chemistry","Pathology","Serotonin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T13:51:41.278443Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}