{"doi":"10.1139/y56-055","title":"STUDIES OF CERTAIN ANTIHISTAMINES AS ANTAGONISTS OF THE HYPERTENSIVE AND ANGIOTOXIC PROPERTIES OF DESOXYCORTICOSTERONE ACETATE IN THE RAT","abstract":"<jats:p> Three antihistamine agents, Phenergan, Benzodionole, and Trimeton have been studied for their ability to antagonize the hypertensive and cardiovascular-renal effects of desoxycorticosterone acetate in the unilaterally-nephrectomized, salt-treated, castrate male rat. In the order named all compounds produced only slight inhibition of the hypertensive and cardiotrophic action of desoxycorticosterone acetate and afforded virtually no protection against either the nephrotrophic or angiotoxic effects of this steroid as seen in the kidney, heart, and pancreatic, arterioles. </jats:p>","journal":"Canadian Journal of Biochemistry and Physiology","year":1956,"id":36169,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":183723,"name":"Floyd R. Skelton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"13316577","pmcid":null,"openalex_id":"https://openalex.org/W1990048714","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.02815622,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining","oa_locations":[{"url":"http://www.nrcresearchpress.com/doi/pdf/10.1139/y56-055","host_type":"publisher"},{"url":"https://doi.org/10.1139/y56-055","host_type":"journal"}],"fields_of_study":["Hormonal Regulation and Hypertension","Hormonal and reproductive studies","Eicosanoids and Hypertension Pharmacology"],"mesh_terms":["Animals","Rats","Hypertension","Desoxycorticosterone","Histamine Antagonists","Histamine H1 Antagonists","Anti-Allergic Agents","Desoxycorticosterone Acetate"],"keywords":["Desoxycorticosterone Acetate","Antihistamine","Endocrinology","Chemistry","Internal medicine","Pharmacology","Medicine","Antihistaminics/effects","Hypertension/experimental","Desoxycorticosterone/antagonists"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T14:36:07.356901Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}