{"doi":"10.1139/y04-108","title":"Receptors subtypes involved in adenosine-mediated modulation of norepinephrine release from cardiac nerve terminals","abstract":"<jats:p> The objective of this study was to determine which adenosine receptor subtypes were involved in the modulation of norepinephrine release from cardiac nerve terminals. In addition, the persistence of adenosine-mediated effects was evaluated. Rat hearts attached to the stellate ganglion were isolated and perfused. The ganglion was electrically stimulated twice (S1 and S2), allowing 10 min between the stimulations. To determine adenosine receptor subtypes, selective and nonselective adenosine agonists and antagonists were infused following S1 and until the end of S2. To evaluate the persistence of adenosine-mediated effect on norepinephrine release, the stellate ganglion was stimulated a third (S3) and fourth (S4) time. Coronary effluents were collected to determine norepinephrine content. Adenosine and a selective A<jats:sub>1</jats:sub> receptor agonist, CCPA, inhibited norepinephrine release by 49% and 54%, respectively. This effect was reversed by simultaneous infusion of nonspecific (8-SPT) and specific (DPCPX) A<jats:sub>1</jats:sub> receptor antagonists. Selective A<jats:sub>2A</jats:sub> (CGS 21680) and A<jats:sub>3</jats:sub> (AB-MECA) receptor agonists had no discernible effect on norepinephrine release. Similarly, adenosine A<jats:sub>2A</jats:sub> receptor antagonists CSC and DMPX did not alter the dose-response relation between norepinephrine release and adenosine. Finally, the inhibitory effects of adenosine on norepinephrine release did not persist 10 min subsequent to the removal of adenosine. Adenosine inhibited norepinephrine release primarily via the adenosine A<jats:sub>1</jats:sub> receptor. This effect of adenosine was of short duration. Adenosine A<jats:sub>2A </jats:sub>and A<jats:sub>3</jats:sub> receptors were either absent or functionally insignificant in the regulation of norepinephrine release in the rat heart.Key words: adenosine, norepinephrine, receptor, rat, neurotransmitters. </jats:p>","journal":"Canadian Journal of Physiology and Pharmacology","year":2004,"id":672853,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1754217,"name":"Eugene S Chung","orcid":null,"position":1,"is_corresponding":false},{"id":1758050,"name":"Arash Nabi","orcid":null,"position":2,"is_corresponding":false},{"id":1758051,"name":"Katarina Skalova","orcid":null,"position":3,"is_corresponding":false},{"id":1758052,"name":"Richard A Fenton","orcid":null,"position":4,"is_corresponding":false},{"id":1758053,"name":"James G Dobson, Jr.","orcid":null,"position":5,"is_corresponding":false},{"id":1758054,"name":"Theo E Meyer","orcid":null,"position":6,"is_corresponding":false},{"id":1758049,"name":"Mojca Lorbar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-08-16T11:21:56.127481Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}