{"doi":"10.1139/o99-048","title":"SR-related proteins and the processing of messenger RNA precursors","abstract":"<jats:p> The processing of messenger RNA precursors (pre-mRNA) to mRNA in metazoans requires a large number of proteins that contain domains rich in alternating arginine and serine residues (RS domains). These include members of the SR family of splicing factors and proteins that are structurally and functionally distinct from the SR family, collectively referred to below as SR-related proteins. Both groups of RS domain proteins function in constitutive and regulated pre-mRNA splicing. Recently, several SR-related proteins have been identified that are associated with the transcriptional machinery. Other SR-related proteins are associated with mRNA 3prime end formation and have been implicated in export. We review these findings and evidence that proteins containing RS domains may play a fundamental role in coordinating different steps in the synthesis and processing of pre-mRNA.Key words: SR protein, RNA polymerase, spliceosome, polyadenylation, nuclear matrix. </jats:p>","journal":"Biochemistry and Cell Biology","year":1999,"id":636079,"datarank":0.736898232860408,"base_score":4.912654885736052,"endowment":4.912654885736052,"self_citation_contribution":0.736898232860408,"citation_network_contribution":0.0,"self_endowment_contribution":0.736898232860408,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":135,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1650561,"name":"John AL Bowman","orcid":null,"position":1,"is_corresponding":false},{"id":1650563,"name":"Susan McCracken","orcid":null,"position":2,"is_corresponding":false},{"id":1650565,"name":"Emanuel Rosonina","orcid":null,"position":3,"is_corresponding":false},{"id":1650559,"name":"Benjamin J Blencowe","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SR-related proteins and the processing of messenger RNA precursors","abstract":"<jats:p> The processing of messenger RNA precursors (pre-mRNA) to mRNA in metazoans requires a large number of proteins that contain domains rich in alternating arginine and serine residues (RS domains). These include members of the SR family of splicing factors and proteins that are structurally and functionally distinct from the SR family, collectively referred to below as SR-related proteins. Both groups of RS domain proteins function in constitutive and regulated pre-mRNA splicing. Recently, several SR-related proteins have been identified that are associated with the transcriptional machinery. Other SR-related proteins are associated with mRNA 3prime end formation and have been implicated in export. We review these findings and evidence that proteins containing RS domains may play a fundamental role in coordinating different steps in the synthesis and processing of pre-mRNA.Key words: SR protein, RNA polymerase, spliceosome, polyadenylation, nuclear matrix. </jats:p>","is_dataset_classified":null,"base_score":4.912654885736052,"endowment":4.912654885736052,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10546891","pmcid":null,"openalex_id":"https://openalex.org/W2005052610","authors":[],"funders":[],"total_grants":0,"fwci":3.1722,"citation_percentile":0.92142009,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":3},{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":4},{"year":2017,"count":5},{"year":2019,"count":5},{"year":2020,"count":1},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining","oa_locations":[{"url":"https://cdnsciencepub.com/doi/pdf/10.1139/o99-048","host_type":"publisher"},{"url":"https://doi.org/10.1139/o99-048","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10546891","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","RNA modifications and cancer","RNA Interference and Gene Delivery"],"mesh_terms":["Serine-Arginine Splicing Factors","Animals","Humans","Models, Biological","Nuclear Proteins","Phosphoproteins","Phosphorylation","RNA Precursors","RNA Splicing","RNA, Messenger","Transcription, Genetic","RNA-Binding Proteins"],"keywords":["SR protein","RNA splicing","Polyadenylation","Messenger RNA","Precursor mRNA","Spliceosome","Biology","RNA-binding protein","Cell biology","Post-transcriptional modification","Mature messenger RNA","RNA","Five-prime cap","Messenger RNP","Genetics","RNA editing","Translation (biology)","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T16:06:55.087332Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}