{"doi":"10.1139/o99-001","title":"The <i>Cdx-1</i> and <i>Cdx-2</i> homeobox genes in the intestine","abstract":"<jats:p> The past years have witnessed an increasing number of reports relative to homeobox genes in endoderm-derived tissues. In this review, we focus on the caudal-related Cdx-1 and Cdx-2 homeobox genes to give an overview of the in vivo, in vitro, and ex vivo approaches that emphasize their primary role in intestinal development and in the control of intestinal cell proliferation, differentiation, and identity. The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed.Key words: caudal, epithelial cell proliferation and differentiation, cancer. </jats:p>","journal":"Biochemistry and Cell Biology","year":1998,"id":22612,"datarank":11.084619193742387,"base_score":5.25227342804663,"endowment":5.25227342804663,"self_citation_contribution":0.7878410142069946,"citation_network_contribution":10.296778179535393,"self_endowment_contribution":0.7878410142069946,"citer_contribution":10.296778179535393,"corpus_percentile":null,"corpus_rank":null,"citation_count":190,"citer_count":177,"citers_with_citation_signal":168,"citers_with_endowment":168,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":141589,"name":"Claire Domon-Dell","orcid":null,"position":1,"is_corresponding":false},{"id":141590,"name":"Michèle Kedinger","orcid":null,"position":2,"is_corresponding":false},{"id":141591,"name":"Isabelle Duluc","orcid":null,"position":3,"is_corresponding":false},{"id":141588,"name":"Jean-Noël Freund","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.25227342804663,"endowment":5.25227342804663,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10392709","pmcid":null,"openalex_id":"https://openalex.org/W1992581153","authors":[],"funders":[],"total_grants":0,"fwci":2.4325,"citation_percentile":0.88598392,"influential_citations":1,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":8},{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":"http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining","oa_locations":[{"url":"https://cdnsciencepub.com/doi/pdf/10.1139/o99-001","host_type":"publisher"},{"url":"https://doi.org/10.1139/o99-001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10392709","host_type":"repository"},{"url":"https://hal.science/hal-03817632","host_type":"repository"}],"fields_of_study":["Digestive system and related health","Epigenetics and DNA Methylation","Congenital heart defects research","Biology","Medicine","Animals","Avian Proteins","CDX2 Transcription Factor","Cell Differentiation","Cell Division","Chick Embryo","Drosophila Proteins","Drosophila melanogaster","Epithelium","Gastrointestinal Neoplasms","Gene Expression Regulation, Developmental","Genes, Homeobox","Homeodomain Proteins","Humans","Intestines","Mice","Models, Biological","Trans-Activators","Transcription Factors"],"mesh_terms":["CDX2 Transcription Factor","Animals","Cell Differentiation","Cell Division","Chick Embryo","Drosophila melanogaster","Epithelium","Gastrointestinal Neoplasms","Genes, Homeobox","Humans","Intestines","Models, Biological","Transcription Factors","Trans-Activators","Homeodomain Proteins","Gene Expression Regulation, Developmental","Drosophila Proteins","Avian Proteins","Mice"],"keywords":["Homeobox","Homeobox A1","CDX2","HNF1B","Homeobox protein Nkx-2.5","Biology","Endoderm","Gene","Genetics","Carcinogenesis","DLX5","In vivo","EMX2","Cell biology","Cellular differentiation","Transcription factor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T14:31:43.546498Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}