{"doi":"10.1139/m72-023","title":"Effect of chloramphenicol on its biosynthesis by <i>Streptomyces</i> species 3022<i>a</i>","abstract":"<jats:p> Measurements of (<jats:sup>3</jats:sup>H) chloramphenicol production in cultures of Streptomyces species 3022a grown on a medium containing (6-<jats:sup>3</jats:sup>H) D-glucose and (3-<jats:sup>14</jats:sup>C) chloramphenicol showed that chloramphenicol inhibits its own biosynthesis. Similar results were obtained in cultures supplemented with the antibacterial p-methylthio- analogue of chloramphenicol. Here synthesis of the antibiotic was completely suppressed until the concentration of analogue had been reduced by inactivating enzymes. In contrast, the L-threo- and p-methylsulfonyl- analogues did not delay growth of the organism and had little effect on chloramphenicol biosynthesis. However, like chloramphenicol and its p-methylthio- analogue, the L-threo and p-methylsulfonyl compounds were degraded. Degradation of chloramphenicol and the p-methylsulfonyl-analogue ceased when endogenously produced antibiotic reached a concentration of 10–30 mg/liter, suggesting that changes in cell permeability are associated with the onset of chloramphenicol synthesis. </jats:p>","journal":"Canadian Journal of Microbiology","year":1972,"id":30721,"datarank":2.498780056330732,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":1.98368197565796,"self_endowment_contribution":0.515098080672772,"citer_contribution":1.98368197565796,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":22,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":166270,"name":"L. C. Vining","orcid":null,"position":1,"is_corresponding":false},{"id":166269,"name":"V. S. Malik","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"5018695","pmcid":null,"openalex_id":"https://openalex.org/W2019681366","authors":[],"funders":[],"total_grants":0,"fwci":2.7245,"citation_percentile":0.90012092,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining","oa_locations":[{"url":"http://www.nrcresearchpress.com/doi/pdf/10.1139/m72-023","host_type":"publisher"},{"url":"https://doi.org/10.1139/m72-023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/5018695","host_type":"repository"}],"fields_of_study":["Analytical Chemistry and Chromatography","Microbial Natural Products and Biosynthesis","Chemical Synthesis and Analysis","Biology","Medicine","Chemistry","Carbon Isotopes","Cell Membrane Permeability","Chloramphenicol","Culture Media","Glucose","Streptomyces","Time Factors","Tritium"],"mesh_terms":["Carbon Isotopes","Cell Membrane Permeability","Chloramphenicol","Culture Media","Glucose","Streptomyces","Time Factors","Tritium"],"keywords":["Chloramphenicol","Biosynthesis","Streptomyces","Enzyme","Antibiotics","Biochemistry","Biology","Microbiology","Chemistry","Bacteria"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T04:30:18.824943Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}