{"doi":"10.1139/cjpp-2012-0261","title":"Effects of exercise on monocrotaline-induced changes in right heart function and pulmonary artery remodeling in rats","abstract":"<jats:p> Pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT) is an experimental protocol of right heart failure. We analyzed the role of exercise training on the right ventricle structure and function, pulmonary artery remodeling, and GSK-3β expression. Rats were divided among the following groups: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), and trained monocrotaline (TM). Rats underwent exercise training for a period of 5 weeks, with 3 weeks post-MCT injection. Rats in the SM and TM groups presented with an increase in right ventricle hypertrophy indexes and lung congestion. The right ventricular end diastolic pressure (RVEDP), right ventricular systolic pressure (RVSP), and its minimum and maximal pressure derivates were increased in the SM and TM groups. The right ventricle interstitial volume pulmonary artery thickness and p-GSK-3β/GSK-3β were increased in the MCT groups as compared with the control groups. The TM group had a reduction in interstitial volume, p-GSK-3β/GSK-3β ratio, pulmonary artery thickness, RVEDP, and an increase in intramyocardial vessels volume as compared with the SM group. The overall results have shown that the exercise protocol used promoted positive changes in right ventricle and pulmonary artery remodeling. These observations also suggest that structural remodeling may be influenced by signaling proteins, such as GSK-3β. </jats:p>","journal":"Canadian Journal of Physiology and Pharmacology","year":2013,"id":26937,"datarank":2.3807801503609936,"base_score":4.07753744390572,"endowment":4.07753744390572,"self_citation_contribution":0.611630616585858,"citation_network_contribution":1.7691495337751353,"self_endowment_contribution":0.611630616585858,"citer_contribution":1.7691495337751353,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":48,"citers_with_citation_signal":39,"citers_with_endowment":39,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":154676,"name":"Rafaela Siqueira","orcid":null,"position":1,"is_corresponding":false},{"id":154677,"name":"Cristiano Urbano Becker","orcid":null,"position":2,"is_corresponding":false},{"id":154678,"name":"Tânia Gatelli Fernandes","orcid":null,"position":3,"is_corresponding":false},{"id":154679,"name":"Karla Maria Pires","orcid":null,"position":4,"is_corresponding":false},{"id":154680,"name":"Samuel Santos Valença","orcid":null,"position":5,"is_corresponding":false},{"id":154681,"name":"Maristela Padilha Souza-Rabbo","orcid":null,"position":6,"is_corresponding":false},{"id":154682,"name":"Alex Sander Araujo","orcid":null,"position":7,"is_corresponding":false},{"id":154683,"name":"Adriane Belló-Klein","orcid":null,"position":8,"is_corresponding":false},{"id":154675,"name":"Rafael Colombo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.07753744390572,"endowment":4.07753744390572,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23368696","pmcid":null,"openalex_id":"https://openalex.org/W2094468907","authors":[],"funders":[],"total_grants":0,"fwci":4.5194,"citation_percentile":0.94948975,"influential_citations":5,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":4},{"year":2015,"count":6},{"year":2016,"count":8},{"year":2017,"count":7},{"year":2018,"count":5},{"year":2019,"count":3},{"year":2020,"count":7},{"year":2021,"count":4},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":"http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining","oa_locations":[{"url":"http://www.nrcresearchpress.com/doi/full-xml/10.1139/cjpp-2012-0261","host_type":"publisher"},{"url":"http://www.nrcresearchpress.com/doi/pdf/10.1139/cjpp-2012-0261","host_type":"publisher"},{"url":"https://doi.org/10.1139/cjpp-2012-0261","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23368696","host_type":"repository"}],"fields_of_study":["Pulmonary Hypertension Research and Treatments","Cardiovascular Function and Risk Factors","Cardiovascular Effects of Exercise","Medicine","Animals","Glycogen Synthase Kinase 3","Glycogen Synthase Kinase 3 beta","Heart Ventricles","Hemodynamics","Male","Monocrotaline","Physical Conditioning, Animal","Pulmonary Artery","Rats","Rats, Wistar","Ventricular Function, Right","Ventricular Remodeling"],"mesh_terms":["Glycogen Synthase Kinase 3 beta","Animals","Heart Ventricles","Hemodynamics","Male","Physical Conditioning, Animal","Pulmonary Artery","Ventricular Function, Right","Monocrotaline","Rats, Wistar","Ventricular Remodeling","Glycogen Synthase Kinase 3","Rats"],"keywords":["Ventricle","Medicine","Pulmonary artery","Right ventricular hypertrophy","Cardiology","Internal medicine","Pulmonary artery banding","Pulmonary hypertension","Ventricular remodeling","Muscle hypertrophy","Lung","Ventricular pressure","Pressure overload","Hemodynamics","Heart failure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T16:05:18.326062Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}